Department of Plastic and Aesthetic Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Hum Genomics. 2023 Mar 17;17(1):23. doi: 10.1186/s40246-023-00470-y.
Blood metabolites are important to various aspects of our health. However, currently, there is little evidence about the role of circulating metabolites in the process of skin aging.
To examine the potential effects of circulating metabolites on the process of skin aging.
In the primary analyses, we applied several MR methods to study the associations between 249 metabolites and facial skin aging risk. In the secondary analyses, we replicated the analyses with another array of datasets including 123 metabolites. MR Bayesian model averaging (MR-BMA) method was further used to prioritize the metabolites for the identification of predominant metabolites that are associated with skin aging.
In the primary analyses, only the unsaturation degree of fatty acids was found significantly associated with skin aging with the IVW method after multiple testing (odds ratio = 1.084, 95% confidence interval = 1.049-1.120, p = 1.737 × 10). Additionally, 11 out of 17 unsaturation-related biomarkers showed a significant or suggestively significant causal effect [p < 0.05 and > 2 × 10 (0.05/249 metabolites)]. In the secondary analyses, seven metabolic biomarkers were found significantly associated with skin aging [p < 4 × 10 (0.05/123)], while six of them were related to the unsaturation degree. MR-BMA method validated that the unsaturation degree of fatty acids plays a dominant role in facial skin aging.
Our study used systemic MR analyses and provided a comprehensive atlas for the associations between circulating metabolites and the risk of facial skin aging. Genetically proxied unsaturation degree of fatty acids was highlighted as a dominant factor correlated with the risk of facial skin aging.
血液代谢物对我们健康的各个方面都很重要。然而，目前关于循环代谢物在皮肤衰老过程中的作用的证据很少。
研究循环代谢物对皮肤衰老过程的潜在影响。
在主要分析中，我们应用了几种 MR 方法来研究 249 种代谢物与面部皮肤衰老风险之间的关联。在次要分析中，我们使用了另一组包括 123 种代谢物的数据集来复制分析。MR 贝叶斯模型平均 (MR-BMA) 方法进一步用于优先确定与皮肤衰老相关的主要代谢物。
在主要分析中，只有脂肪酸的不饱和程度在经过多次检验后，用 IVW 方法发现与皮肤衰老显著相关（比值比=1.084，95%置信区间=1.049-1.120，p=1.737×10）。此外，17 个不饱和相关生物标志物中有 11 个显示出显著或提示性的因果效应[p<0.05 和>2×10（0.05/249 代谢物）]。在次要分析中，发现有七个代谢生物标志物与皮肤衰老显著相关[p<4×10（0.05/123）]，其中六个与不饱和程度有关。MR-BMA 方法验证了脂肪酸的不饱和程度在面部皮肤衰老中起着主导作用。
本研究使用系统的 MR 分析方法，为循环代谢物与面部皮肤衰老风险之间的关联提供了全面的图谱。遗传上接近的脂肪酸不饱和程度被强调为与面部皮肤衰老风险相关的主要因素。
