State Key Laboratory of Primate Biomedical Research and Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming 650500, China.
Yi Chuan. 2023 Mar 20;45(3):198-211. doi: 10.16288/j.yczz.22-306.
In the central nervous system, oligodendrocytes are highly specialized myelinating glial cells that originate from oligodendrocyte precursor cells. In the past, research centered on the oligodendrocyte development, myelination, and the role of oligodendrocyte lineage in neurological disorders. The emerging single-cell RNA sequencing technology is a new tool to specifically identify cell-types at the transcriptome level, and recently have also been used to investigate oligodendrocyte lineage-related issues. In this review, we summarize the recent developments of single-cell RNA sequencing technologies and their application in the oligodendroglia heterogeneity and neurological disorders, thereby providing new ideas and references for the utilization of single-cell RNA sequencing technology in the research field of oligodendrocyte lineage and neurological disorders.
在中枢神经系统中，少突胶质细胞是高度特化的髓鞘形成胶质细胞，起源于少突胶质前体细胞。过去，研究主要集中在少突胶质细胞的发育、髓鞘形成以及少突胶质细胞谱系在神经疾病中的作用。新兴的单细胞 RNA 测序技术是一种在转录组水平上专门鉴定细胞类型的新工具，最近也被用于研究少突胶质细胞谱系相关问题。在这篇综述中，我们总结了单细胞 RNA 测序技术的最新进展及其在少突胶质细胞异质性和神经疾病中的应用，为单细胞 RNA 测序技术在少突胶质细胞谱系和神经疾病研究领域的应用提供了新的思路和参考。
