Hawai'i Center for AIDS, Department of Medicine, John A. Burns School of Medicine.
Department of Quantitative Health Sciences, John A. Burns School of Medicine.
AIDS. 2023 Jun 1;37(7):1177-1179. doi: 10.1097/QAD.0000000000003534. Epub 2023 Mar 3.
This study evaluated the association between the transmigration of monocyte subpopulations that contributes to atherosclerosis development, along with surrogate biomarkers of inflammation and atherosclerosis, through carotid intima-media thickness (cIMT) measurements of 72 people with HIV (PWH) on suppressive antiretroviral therapy (ART). We found that the transmigration of intermediate monocytes was positively correlated with D-dimer and cIMT, suggesting that intermediate monocytes may have a greater propensity to promote cardiovascular disease (CVD) in PWH on ART.
本研究评估了在接受抑制性抗逆转录病毒疗法 (ART) 的 72 名 HIV 感染者 (PWH) 中，通过颈动脉内膜中层厚度 (cIMT) 测量，单核细胞亚群迁移与动脉粥样硬化发展相关的炎症和动脉粥样硬化替代生物标志物之间的关系。我们发现中间型单核细胞的迁移与 D-二聚体和 cIMT 呈正相关，这表明中间型单核细胞可能在接受 ART 的 PWH 中更倾向于促进心血管疾病 (CVD)。
