Department of Urology, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan.
School of Medicine, Tzu Chi University, Hualian, Taiwan.
PLoS One. 2023 Mar 16;18(3):e0283040. doi: 10.1371/journal.pone.0283040. eCollection 2023.
This study investigates age-specific prostate-specific antigen (PSA) distributions in Taiwanese men and recommends reference ranges for this population after comparison with other studies. From January 1999 to December 2016, a total of 213,986 Taiwanese men aged above 19 years old without history of prostate cancer, urinary tract infection, or prostate infection were recruited from the Taiwan MJ cohort, an ongoing prospective cohort of health examinations conducted by the MJ Health Screening Center in Taiwan. Participants were divided into seven age groups. Simple descriptive statistical analyses were carried out and quartiles and 95th percentiles were calculated for each group as reference ranges for serum PSA in screening for prostate cancer in Taiwanese men. Serum PSA concentration correlated with age (r = 0.274, p<0.001). The median serum PSA concentration (5th to 95th percentile) ranged from 0.7 ng/ml (0.3 to 1.8) for men 20-29 years old (n = 6,382) to 1.6 ng/ml (0.4 to 8.4) for men over 79 years old (n = 504). The age-specific PSA reference ranges are as follows: 20-29 years, 1.80 ng/ml; 30-39 years, 1.80 ng/ml; 40-49 years, 2.0 ng/ml; 50-59 years, 3.20 ng/ml; 60-69 years, 5.60 ng/ml; 70-79 years, 7.40 ng/ml; over 80 years, 8.40 ng/ml. Almost no change occurred in the median serum PSA value in men 50 years old or younger, while a gradual increase was observed in men over 50. Taiwanese men aged 60 years above showed higher 95th percentile serum PSA values compared to Caucasian men and men in other Asian countries but were closer to those of Asian American and African American men. Results indicate significantly different PSA levels correlating to different ethnicities, suggesting that Oesterling's age-specific PSA reference ranges might not be appropriate for Taiwanese men. Our results should be further studied to validate the age-specific PSA reference ranges for Taiwanese men presented in this study.
本研究旨在调查台湾男性特定年龄的前列腺特异性抗原（PSA）分布情况，并与其他研究进行比较后，为该人群推荐参考范围。1999 年 1 月至 2016 年 12 月，从台湾 MJ 队列中招募了 213986 名年龄在 19 岁以上、无前列腺癌、尿路感染或前列腺感染史的台湾男性。MJ 健康筛查中心在台湾进行了一项正在进行的前瞻性健康检查队列研究。参与者被分为 7 个年龄组。进行了简单的描述性统计分析，并计算了每个组的四分位数和第 95 百分位数，作为台湾男性前列腺癌筛查中血清 PSA 的参考范围。血清 PSA 浓度与年龄相关（r = 0.274，p<0.001）。20-29 岁（n = 6382）男性血清 PSA 浓度中位数（5-95 百分位数）为 0.7ng/ml（0.3-1.8），70 岁以上（n = 504）男性为 1.6ng/ml（0.4-8.4）。特定年龄的 PSA 参考范围如下：20-29 岁，1.80ng/ml；30-39 岁，1.80ng/ml；40-49 岁，2.0ng/ml；50-59 岁，3.20ng/ml；60-69 岁，5.60ng/ml；70-79 岁，7.40ng/ml；80 岁以上，8.40ng/ml。50 岁及以下男性的血清 PSA 值中位数几乎没有变化，而 50 岁以上男性的血清 PSA 值逐渐增加。60 岁以上的台湾男性的第 95 百分位血清 PSA 值高于白种男性和其他亚洲国家的男性，但与亚裔美国男性和非裔美国男性更为接近。结果表明，与不同种族相关的 PSA 水平存在显著差异，提示 Oesterling 的特定年龄 PSA 参考范围可能不适用于台湾男性。本研究为台湾男性提供的特定年龄 PSA 参考范围需要进一步研究验证。
