中国无前列腺癌男性的年龄特异性前列腺特异性抗原参考范围。
Age-specific PSA reference ranges in Chinese men without prostate cancer.
作者信息
Liu Zhi-Yong, Sun Ying-Hao, Xu Chuan-Liang, Gao Xu, Zhang Luo-Man, Ren Shan-Cheng
机构信息
Urology Department, Shanghai Changhai Hospital, The Second Military Medical University, Shanghai, China.
出版信息
Asian J Androl. 2009 Jan;11(1):100-3. doi: 10.1038/aja.2008.17. Epub 2008 Dec 1.
This study is to determine age-specific prostate-specific antigen (PSA) distributions in Chinese men without prostate cancer (PC) and to recommend reference ranges for this population after comparison with other studies. From September 2003 to December 2006, 9 374 adult men aged from 18 to 96 years agreed to participate in the study. After all cases of PC were excluded, 8 422 adult men participated in statistical analysis and were divided into five age groups. Simple descriptive statistical analyses were carried out and quartiles and 95th percentiles were calculated for each age group. The age-specific PSA reference ranges are as follows: 40-49 years, 2.15 ng mL(-1); 50-59 years, 3.20 ng mL(-1); 60-69 years, 4.10 ng mL(-1); 70-79 years, 5.37 ng mL(-1). The results indicate that the ethnic differences in PSA levels are obvious. The currently adopted Oesterling's age-specific PSA reference ranges are not appropriate for Chinese men. The reference ranges of this study should be more suitable to Chinese men.
本研究旨在确定中国非前列腺癌（PC）男性特定年龄的前列腺特异性抗原（PSA）分布情况，并与其他研究进行比较后，为该人群推荐参考范围。2003年9月至2006年12月，9374名年龄在18至96岁的成年男性同意参与本研究。排除所有PC病例后，8422名成年男性参与统计分析，并被分为五个年龄组。进行了简单的描述性统计分析，并计算了每个年龄组的四分位数和第95百分位数。特定年龄的PSA参考范围如下：40 - 49岁，2.15 ng/mL；50 - 59岁，3.20 ng/mL；60 - 69岁，4.10 ng/mL；70 - 79岁，5.37 ng/mL。结果表明，PSA水平的种族差异明显。目前采用的奥斯特林特定年龄PSA参考范围不适用于中国男性。本研究的参考范围应更适合中国男性。
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