College of Pharmacy, Seoul National University, Seoul, Republic of Korea.
College of Pharmacy, Yeungnam University, Gyeongsangbuk-do, Republic of Korea.
J Public Health (Oxf). 2023 Aug 28;45(3):645-653. doi: 10.1093/pubmed/fdad022.
With the aging population, older adults are more likely to receive outpatient care. Therefore, it is necessary to identify drug-related problems (DRPs) and potentially inappropriate medications (PIMs) associated with adverse clinical outcomes in community-dwelling older adults. This study aimed to develop a medication review tool for community-dwelling older adults in Korea.
We developed the tool using three steps: (i) establishment of a preliminary list by reviewing 21 existing tools, (ii) a two-round Delphi survey to evaluate clinical appropriateness and (iii) a two-round Delphi survey to evaluate applicability. The list was categorized into 23 diseases/conditions with five types of DRPs. The interventions for each item have been described.
The preliminary list contained 100 items. The final list contained 81 items, including 17 general PIMs, 26 PIMs under specific disease/conditions, 16 potential drug interactions, 20 potential omissions and 2 PIMs requiring dose adjustment.
We developed a disease-based explicit medication review tool that can be used in primary care. This tool would assist primary care healthcare providers in identifying inappropriate medication use, which may help reduce adverse clinical consequences in older adults. Further studies are required to validate the clinical efficacy of this tool.
随着人口老龄化,老年人更有可能接受门诊护理。因此,有必要识别与社区居住的老年人不良临床结局相关的药物相关问题 (DRP) 和潜在不适当药物 (PIM)。本研究旨在为韩国的社区居住老年人开发一种药物审查工具。
我们通过三个步骤开发了该工具:(i) 通过审查 21 种现有工具建立初步清单,(ii) 进行两轮 Delphi 调查以评估临床适宜性,以及 (iii) 进行两轮 Delphi 调查以评估适用性。该清单分为 23 种疾病/病症,有五种类型的 DRP。每个项目的干预措施都已描述。
初步清单包含 100 个项目。最终清单包含 81 个项目,包括 17 种一般 PIM、26 种特定疾病/病症下的 PIM、16 种潜在药物相互作用、20 种潜在遗漏和 2 种需要剂量调整的 PIM。
我们开发了一种基于疾病的明确药物审查工具,可用于初级保健。该工具将帮助初级保健医疗保健提供者识别不适当的药物使用,这可能有助于减少老年人的不良临床后果。需要进一步的研究来验证该工具的临床疗效。