School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia.
School of Allied Health, University of Western Australia, Perth, Western Australia, Australia.
Intern Med J. 2024 Jun;54(6):980-1002. doi: 10.1111/imj.16322. Epub 2024 Feb 2.
Older people are at high risk of medicines-related harms. otentially inappropriate medicines (PIMs) list has been developed to assist clinicians and researchers to identify medicines with risks that may potentially outweigh their benefits in order to improve medication management and safety.
To develop a list of PIMs for older people specific to Australia.
The study obtained expert consensus through the utilisation of the Delphi technique in Australia. A total of 33 experts partook in the initial round, while 32 experts engaged in the subsequent round. The primary outcomes encompass medicines assessed as potentially inappropriate, the specific contexts in which their inappropriateness arises and potentially safer alternatives.
A total of 16 medicines or medicine classes had one or more medicines deemed as potentially inappropriate in older people. Up to 19 medicines or medicine classes had specific conditions that make them more potentially inappropriate, while alternatives were suggested for 16 medicines or classes.
An explicit PIMs list for older people living in Australia has been developed containing 19 drugs/drug classes. The PIMs list is intended to be used as a guide for clinicians when assessing medication appropriateness in older people in Australian clinical settings and does not substitute individualised treatment advice from clinicians.
老年人面临较高的用药相关伤害风险。潜在不适当用药（PIM）清单旨在帮助临床医生和研究人员识别风险可能超过获益的药物，以改善药物管理和安全性。
为澳大利亚老年人制定特定的 PIM 清单。
本研究通过在澳大利亚使用德尔菲技术获得专家共识。共有 33 名专家参与了首轮研究，32 名专家参与了后续轮次研究。主要结局包括被评估为潜在不适当的药物、其不适当性出现的具体情况以及潜在更安全的替代药物。
共有 16 种药物或药物类别中的一种或多种药物被认为对老年人潜在不适当。多达 19 种药物或药物类别存在使其更具潜在不适当性的特定情况，同时为 16 种药物或药物类别提出了替代药物。
为澳大利亚的老年人制定了一份明确的 PIM 清单，其中包含 19 种药物/药物类别。该 PIM 清单旨在作为临床医生在澳大利亚临床环境中评估老年人药物适宜性的指南，不能替代临床医生的个体化治疗建议。
