评价系统性 ω-3 多不饱和脂肪酸对兔模型正畸牙齿移动的影响：随机对照试验。
Evaluation of systemic Omega-3 PUFAs effect on orthodontic tooth movement in a rabbit model: RCT.
出版信息
Angle Orthod. 2023 Jul 1;93(4):476-481. doi: 10.2319/110222-750.1.
OBJECTIVES
To evaluate the effect of systemic administration of omega-3 fatty acids on orthodontic tooth movement (OTM) with histological analysis.
MATERIALS AND METHODS
OTM was induced in 20 adult albino New Zealand rabbits, divided into omega-3 and control groups, with nickel-titanium coil springs for 21 days. Omega-3 or saline was given every day via oral gavage during the experimental period. Animals were sacrificed for histomorphometric analysis of alveolar bone remodeling after 21 days of OTM.
RESULTS
A significant difference in OTM amount was found in the third week of OTM with means of 1.445 ± 0.13 and 1.72 ± 0.15 for the experimental and control groups, respectively. Histomorphometric analysis showed a significant reduction in the area of active bone-resorptive lacunae and a significant increase in osteoblastic activity in the omega-3 group after 3 weeks.
CONCLUSIONS
Strong evidence of the osteoclastic inhibitory effect of systemic omega-3 was found, which reduced the percentage and amount of OTM.
目的
通过组织学分析评估全身性给予ω-3 脂肪酸对正畸牙齿移动（OTM）的影响。
材料和方法
将 20 只成年白化新西兰兔分为ω-3 组和对照组，用镍钛螺旋弹簧诱导 OTM 21 天。在实验期间，每天通过口服灌胃给予 ω-3 或生理盐水。在 OTM 21 天后，对牙槽骨改建进行组织形态计量学分析以处死动物。
结果
在 OTM 的第三周，OTM 量有显著差异，实验组和对照组的平均值分别为 1.445±0.13 和 1.72±0.15。组织形态计量学分析显示，在第 3 周时，ω-3 组的活性骨吸收陷窝面积显著减少，成骨细胞活性显著增加。
结论
有强有力的证据表明全身性给予ω-3 具有抑制破骨细胞的作用，从而减少 OTM 的百分比和数量。
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