Huang Jie, Wang Long, Tang Xiang-Ying
Key Laboratory of Material Chemistry for Energy Conversion and Storage, Ministry of Education, Hubei Engineering Research Center for Biomaterials and Medical Protective Materials, Hubei Key Laboratory of Bioinorganic Chemistry & Materia Medica, Semiconductor Chemistry Center, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST), Wuhan 430074, People's Republic of China.
Org Biomol Chem. 2023 Mar 29;21(13):2709-2714. doi: 10.1039/d3ob00280b.
An oxidative cross-coupling of quinoxalinones with indole derivatives B(CF)·HO induced acidochromism of quinoxalinone derivatives was developed under mild and external photocatalyst-free conditions. The reaction shows excellent substrate scope, accommodating a wide range of functional groups. The usefulness of this strategy was demonstrated by the synthesis of the natural products Azacephalandole A and Cephalandole A in high yields. Moreover, the products are fluorophores showing prevalent fluorescence properties with a wide emission range and good relative quantum yields.
喹喔啉酮与吲哚衍生物的氧化交叉偶联反应 在温和且无外部光催化剂的条件下，开发了B(CF)·HO诱导的喹喔啉酮衍生物的酸致变色反应。该反应具有出色的底物范围，能兼容多种官能团。通过高产率合成天然产物氮杂头孢菌素A和头孢菌素A证明了该策略的实用性。此外，产物是荧光团，具有普遍的荧光性质，发射范围宽且相对量子产率良好。
