Department of Internal Medicine, Department of Medical Oncology, Bezmialem Vakif University, Istanbul, Turkey.
Department of General Surgery, Bezmialem Vakif University, Istanbul, Turkey.
Ir J Med Sci. 2023 Dec;192(6):2635-2641. doi: 10.1007/s11845-023-03340-7. Epub 2023 Mar 17.
Colorectal cancer is a common cause of cancer-related deaths. About 1/3 of all cases present with distant metastasis, with the liver as the leading site and the lung as the most common extra-abdominal site.
It was aimed to evaluate the clinical characteristics and the outcomes of colorectal cancer patients with liver or lung metastasis who had received local treatments.
This is a retrospective, cross-sectional, and descriptive study. The study was performed with colorectal cancer patients that referred to the medical oncology clinic of a university hospital between December 2013 and August 2021.
A total number of 122 patients who have received local treatments were included. Radiofrequency ablation was applied in 32 patients (26.2%), metastasis was surgically resected in 84 patients (68.9%), and stereotactic body radiotherapy was preferred in six patients (4.9%). At the first follow-up control after completion of local or multimodal treatment, no residual tumor was determined with radiological assessment in 88 patients (72.1%). The median progression-free survival (16.7 months vs 9.7 months) (p = .000) and the median overall survival (37.3 months vs 25.5 months) (p = .004) of these patients were significantly better than the patients with residual disease.
Local interventions that are applied to highly selected patients may improve the survival of metastatic colorectal cancer patients. A close follow-up after local therapies is important to diagnose recurrent disease because repeated local interventions may be possible to achieve better outcomes.
结直肠癌是癌症相关死亡的常见原因。约有 1/3 的病例存在远处转移，肝脏是主要转移部位，肺是最常见的腹外转移部位。
评估接受局部治疗的结直肠癌伴肝或肺转移患者的临床特征和结局。
这是一项回顾性、横断面和描述性研究。该研究纳入了 2013 年 12 月至 2021 年 8 月期间在一所大学医院肿瘤内科就诊的结直肠癌患者。
共纳入 122 例接受局部治疗的患者。32 例（26.2%）接受射频消融治疗，84 例（68.9%）手术切除转移灶，6 例（4.9%）接受立体定向体部放疗。在局部或多模式治疗完成后的首次随访时，88 例（72.1%）患者经影像学评估确定无残留肿瘤。无残留肿瘤患者的中位无进展生存期（16.7 个月比 9.7 个月）（p=0.000）和中位总生存期（37.3 个月比 25.5 个月）（p=0.004）明显长于有残留疾病的患者。
局部干预措施应用于高度选择的患者可能会改善转移性结直肠癌患者的生存。局部治疗后密切随访对于诊断复发性疾病非常重要，因为反复进行局部干预可能会获得更好的结果。
