癫痫持续状态的治疗：生理学、药理学和未来方向。
Treatment of status epilepticus: Physiology, pharmacology, and future directions.
机构信息
Departments of Neurology and Pediatrics, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California, USA.
出版信息
Epilepsia Open. 2023 May;8 Suppl 1(Suppl 1):S141-S148. doi: 10.1002/epi4.12725. Epub 2023 Apr 20.
Abstract
The review presents retrospective, present views and future perspectives on the treatment of status epilepticus (SE). First, presynaptic, postsynaptic, and extrasynaptic mechanisms underlying sustaining ongoing seizure activity are highlighted. Next, mechanism-based choices of antiseizure medications capable of promptly arresting SE are introduced. Finally, challenges associated with translating the advances in laboratory research in clinical practice are discussed.
摘要
这篇综述回顾了过去、现在和未来对癫痫持续状态（SE）的治疗观点。首先，强调了维持持续癫痫发作活动的突触前、突触后和突触外机制。其次，介绍了能够迅速终止 SE 的基于机制的抗癫痫药物选择。最后，讨论了将实验室研究进展转化到临床实践中所面临的挑战。
相似文献
1
Treatment of status epilepticus: Physiology, pharmacology, and future directions.癫痫持续状态的治疗：生理学、药理学和未来方向。
Epilepsia Open. 2023 May;8 Suppl 1(Suppl 1):S141-S148. doi: 10.1002/epi4.12725. Epub 2023 Apr 20.
2
Drug Trials in Status Epilepticus: Current Evidence and Future Concepts.癫痫持续状态的药物临床试验：当前证据与未来概念。
J Clin Neurophysiol. 2020 Sep;37(5):434-445. doi: 10.1097/WNP.0000000000000713.
3
Preferential Antiseizure Medications in Pediatric Patients with Convulsive Status Epilepticus: A Systematic Review and Network Meta-Analysis.惊厥性癫痫持续状态患儿的首选抗癫痫药物：系统评价和网络荟萃分析。
Clin Drug Investig. 2021 Jan;41(1):1-17. doi: 10.1007/s40261-020-00975-7. Epub 2020 Nov 4.
4
Parenteral Long-Acting Antiseizure Medications Are Used More Often to Treat Seizure Clusters Than Convulsive Status Epilepticus in the Pediatric Emergency Department.在儿科急诊科，静脉注射长效抗癫痫药物更常用于治疗癫痫发作簇，而不是癫痫持续状态。
J Child Neurol. 2022 Jun;37(7):589-598. doi: 10.1177/08830738221077751. Epub 2022 Feb 10.
5
Status epilepticus and refractory status epilepticus management.癫痫持续状态和难治性癫痫持续状态的管理。
Semin Pediatr Neurol. 2014 Dec;21(4):263-74. doi: 10.1016/j.spen.2014.12.006. Epub 2014 Dec 12.
6
Neuroactive steroids for the treatment of status epilepticus.神经活性甾体治疗癫痫持续状态。
Epilepsia. 2013 Sep;54 Suppl 6(0 6):93-8. doi: 10.1111/epi.12289.
7
Treatment of benzodiazepine-refractory status epilepticus: A retrospective, cohort study.苯二氮䓬类药物难治性癫痫持续状态的治疗：一项回顾性队列研究。
Epilepsy Behav. 2023 Mar;140:109093. doi: 10.1016/j.yebeh.2023.109093. Epub 2023 Feb 3.
8
Timing and selection of first antiseizure medication in patients with pediatric status epilepticus.小儿癫痫持续状态患者首次抗癫痫药物的使用时机与选择
Epilepsy Res. 2019 Jan;149:21-25. doi: 10.1016/j.eplepsyres.2018.10.014. Epub 2018 Nov 1.
9
Extrasynaptic γ-aminobutyric acid type A receptor-mediated sex differences in the antiseizure activity of neurosteroids in status epilepticus and complex partial seizures.癫痫持续状态和部分复杂发作中神经甾体的抗惊厥作用存在γ-氨基丁酸 A 型受体介导的突触外性别差异。
Epilepsia. 2019 Apr;60(4):730-743. doi: 10.1111/epi.14693. Epub 2019 Mar 20.
10
Etiology, clinical course and response to the treatment of status epilepticus in children: A 16-year single-center experience based on 602 episodes of status epilepticus.儿童癫痫持续状态的病因、临床过程及治疗反应：基于602例癫痫持续状态发作的16年单中心经验
Eur J Paediatr Neurol. 2015 Sep;19(5):584-90. doi: 10.1016/j.ejpn.2015.05.007. Epub 2015 Jun 19.
引用本文的文献
1
Inhibitory Effects of Cenobamate on Multiple Human Cardiac Ion Channels and Possible Arrhythmogenic Consequences.司巴丁对多种人类心脏离子通道的抑制作用及可能的致心律失常后果
Biomolecules. 2024 Dec 11;14(12):1582. doi: 10.3390/biom14121582.
2
New Pharmacological Therapies in the Treatment of Epilepsy in the Pediatric Population.治疗儿童癫痫的新型药物疗法
J Clin Med. 2024 Jun 18;13(12):3567. doi: 10.3390/jcm13123567.
3
Neurosteroids as Novel Anticonvulsants for Refractory Status Epilepticus and Medical Countermeasures for Nerve Agents: A 15-Year Journey to Bring Ganaxolone from Bench to Clinic.神经甾体作为难治性癫痫持续状态的新型抗惊厥药物和神经毒剂的医疗对策：将加奈索隆从实验室带到临床的 15 年历程。
J Pharmacol Exp Ther. 2024 Jan 17;388(2):273-300. doi: 10.1124/jpet.123.001816.
4
Cenobamate (YKP3089) and Drug-Resistant Epilepsy: A Review of the Literature.依诺贝酸（YKP3089）与耐药性癫痫：文献综述。
Medicina (Kaunas). 2023 Jul 28;59(8):1389. doi: 10.3390/medicina59081389.
本文引用的文献
1
Why ketamine.为什么是氯胺酮。
Epilepsy Behav. 2023 Apr;141:109066. doi: 10.1016/j.yebeh.2022.109066. Epub 2023 Jan 4.
2
Intravenous ganaxolone in pediatric super-refractory status epilepticus: A single hospital experience.静脉注射甘氨酰胺用于小儿超难治性癫痫持续状态：一家医院的经验
Epilepsy Behav Rep. 2022 Oct 6;20:100567. doi: 10.1016/j.ebr.2022.100567. eCollection 2022.
3
Successful treatment of adult Dravet syndrome patients with cenobamate.用司替戊醇成功治疗成年Dravet综合征患者。
Epilepsia. 2022 Dec;63(12):e164-e171. doi: 10.1111/epi.17427. Epub 2022 Oct 14.
4
Intravenous ganaxolone for the treatment of refractory status epilepticus: Results from an open-label, dose-finding, phase 2 trial.静脉注射 ganaxolone 治疗难治性癫痫持续状态：一项开放标签、剂量发现、2 期试验的结果。
Epilepsia. 2022 Sep;63(9):2381-2391. doi: 10.1111/epi.17343. Epub 2022 Jul 10.
5
NBI-921352, a first-in-class, Na1.6 selective, sodium channel inhibitor that prevents seizures in gain-of-function mice, and wild-type mice and rats.NBI-921352 是一种首创的、钠通道选择性抑制剂，可防止功能获得性突变小鼠、野生型小鼠和大鼠发生癫痫。
Elife. 2022 Mar 2;11:e72468. doi: 10.7554/eLife.72468.
6
Resurgent Sodium Current in Neurons of the Cerebral Cortex.大脑皮层神经元中的复苏钠电流
Front Cell Neurosci. 2021 Oct 1;15:760610. doi: 10.3389/fncel.2021.760610. eCollection 2021.
7
Inhibiting with-no-lysine kinases enhances K+/Cl- cotransporter 2 activity and limits status epilepticus.抑制无赖氨酸激酶可增强 K+/Cl-共转运蛋白 2 的活性并限制癫痫持续状态。
Brain. 2022 Apr 29;145(3):950-963. doi: 10.1093/brain/awab343.
8
The Role of Calmodulin vs. Synaptotagmin in Exocytosis.钙调蛋白与突触结合蛋白在胞吐作用中的作用
Front Mol Neurosci. 2021 Aug 5;14:691363. doi: 10.3389/fnmol.2021.691363. eCollection 2021.
9
Positive allosteric modulation of GABA receptors by a novel antiepileptic drug cenobamate.新型抗癫痫药物苯巴比妥对 GABA 受体的正变构调节。
Eur J Pharmacol. 2020 Jul 15;879:173117. doi: 10.1016/j.ejphar.2020.173117. Epub 2020 Apr 20.
10
Early polytherapy for benzodiazepine-refractory status epilepticus.苯二氮䓬类药物难治性癫痫持续状态的早期联合治疗。
Epilepsy Behav. 2019 Dec;101(Pt B):106367. doi: 10.1016/j.yebeh.2019.06.011. Epub 2019 Oct 18.
Zotero 插件