Quattrocolo Giulia, Dunville Keagan, Nigro Maximiliano José
Center for Neural Computation, Egil and Pauline Braathen and Fred Kavli Center for Cortical Microcircuits, Kavli Institute for Systems Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway.
Front Cell Neurosci. 2021 Oct 1;15:760610. doi: 10.3389/fncel.2021.760610. eCollection 2021.
In the late '90, Dr. Indira Raman, at the time a postdoctoral fellow with Dr. Bruce Bean, at Harvard University, identified a new type of sodium current, flowing through the channels that reopens when the membrane is repolarized. This current, called "resurgent Sodium current," was originally identified in cerebellar Purkinje neurons and has now been confirmed in around 20 different neuronal types. Since moving to Northwestern University in 1999 to establish her own research group, Dr. Raman has dedicated great efforts in identifying the mechanisms supporting the resurgent Sodium current and how its biophysical properties shape the firing of the different cell types. Her work has impacted greatly the field of cellular neurophysiology, from basic research to translation neuroscience. In fact, alterations in the resurgent sodium currents have been observed in several neuropathologies, from Huntington's disease to epilepsy. In this Perspective we will focus on the current knowledge on the expression and function of the resurgent Sodium current in neurons of the cerebral cortex and hippocampus. We will also briefly highlight the role of Dr. Raman's as teacher and mentor, not only for her pupils, but for the whole scientific community.
20世纪90年代末，当时作为哈佛大学布鲁斯·比恩博士博士后研究员的英迪拉·拉曼博士，发现了一种新型钠电流，该电流通过在膜复极化时重新开放的通道流动。这种电流被称为“复苏钠电流”，最初在小脑浦肯野神经元中被发现，现在已在大约20种不同的神经元类型中得到证实。自1999年搬到西北大学建立自己的研究小组以来，拉曼博士一直致力于确定支持复苏钠电流的机制，以及其生物物理特性如何塑造不同细胞类型的放电。她的工作对细胞神经生理学领域产生了重大影响，从基础研究到转化神经科学。事实上，在从亨廷顿舞蹈症到癫痫等多种神经病理学中都观察到了复苏钠电流的改变。在这篇观点文章中，我们将聚焦于目前关于大脑皮层和海马体神经元中复苏钠电流的表达和功能的知识。我们还将简要强调拉曼博士作为教师和导师的角色，不仅对她的学生，而且对整个科学界来说都是如此。
