Veterinary Pathology Laboratory, Veterinary Hospital-Universidade Federal de Mato Grosso, Cuiabá, Brazil.
Molecular Biology Laboratory, Veterinary Hospital-Universidade Federal de Mato Grosso, Cuiabá, Brazil.
J Vet Diagn Invest. 2023 May;35(3):304-306. doi: 10.1177/10406387231161340. Epub 2023 Mar 17.
Although the novel Brazilian porcupinepox virus (BPoPV) can infect wild porcupines, its lethality and zoonotic potential are not well-established. In May 2021, a free-ranging neotropical porcupine () rescued from the natural savanna in the Brazilian Cerrado, Mato Grosso State, was presented with a lethal poxviral infection. Clinical signs and PCR detection of BPoPV supported the diagnosis. Poxviral lesions included erythema, exfoliative dermatitis, and erosions involving mainly the face, hindlimb, and vulva. Histologically, the lesions consisted of proliferative and necrotic dermatitis, intraepidermal and follicular pustules, and intracytoplasmic inclusion bodies in keratinocytes. Phylogenetic analysis revealed BPoPV strains closely related to other rodent-infecting poxviruses. This poxviral infection resulted in the death of a specimen of ; the effect on species conservation, and the potential of spillover into humans and other vertebrates remain unknown.
尽管新型巴西豪猪痘病毒（BPoPV）可感染野生豪猪，但它的致死率和人畜共患潜力尚未得到充分证实。2021 年 5 月，一头在巴西塞拉多自然草原上被营救的自由活动的新热带豪猪（），感染了致死性痘病毒。BPoPV 的临床症状和 PCR 检测结果支持该诊断。痘病毒病变包括红斑、剥脱性皮炎和糜烂，主要累及面部、后肢和外阴。组织学上，病变包括增生性和坏死性皮炎、表皮内和滤泡性脓疱以及角朊细胞内的细胞质包涵体。系统发育分析显示，BPoPV 株与其他啮齿动物感染的痘病毒密切相关。这种痘病毒感染导致一只死亡；其对物种保护的影响，以及向人类和其他脊椎动物溢出的潜力尚不清楚。
