Chen Jiafei, Wan Shiqi, Fu Yike, Zhou Yi, Li Xiang, Wang Huiming
The Affiliated Hospital of Stomatology, School of Stomatology, Zhejiang University of Medicine, and Key Laboratory of Oral Biomedical Research of Zhejiang Province, Hangzhou, Zhejiang, 310006, China.
State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou, Zhejiang, 310027, P. R. China.
J Mater Chem B. 2023 Apr 5;11(14):3151-3163. doi: 10.1039/d2tb02699f.
Tissue regeneration and tumor cell killing after surgical resection are the two keys to achieving effective tumor therapy. In this study, an implantable system with combined functions of tumor therapy and tissue repair was constructed. Tannic acid (TA)/Fe nanoparticles with Fenton catalytic activity were loaded with GSH inhibitor BSO drug (BTF), and acted as the therapeutic factor to realize amplified chemodynamic tumor treatment. Bioactive glass (BG) fibers loaded with vascular endothelial growth factor (VEGF) were used as the drug carrier matrix with tissue repair function (BGV). Then the BGV@BTF composite fibers were obtained by anchoring BTF nanoparticles on the surface of BGV fibers. Under tumorous acidic conditions, BTF nanoparticles can be released from the composite fibers, and taken up by tumor cells. Facilitated by BSO with the GSH suppression effect and TA with Fe reducing properties, BTF nanoparticles can realize high oxidative stress in tumor cells and subsequent cell death. In addition, BG fibers and VEGF can both promote tissue regeneration and accelerate postoperative wound healing. The simultaneous suppression of tumor growth and promotion of tissue repair in this work is inspiring in the field of postoperative tumor treatment and recovery.
手术切除后的组织再生和肿瘤细胞杀伤是实现有效肿瘤治疗的两个关键。在本研究中，构建了一种具有肿瘤治疗和组织修复联合功能的可植入系统。负载谷胱甘肽抑制剂BSO药物（BTF）的具有芬顿催化活性的单宁酸（TA）/铁纳米颗粒作为治疗因子，实现放大的化学动力肿瘤治疗。负载血管内皮生长因子（VEGF）的生物活性玻璃（BG）纤维用作具有组织修复功能的药物载体基质（BGV）。然后通过将BTF纳米颗粒锚定在BGV纤维表面获得BGV@BTF复合纤维。在肿瘤酸性条件下，BTF纳米颗粒可从复合纤维中释放，并被肿瘤细胞摄取。在具有谷胱甘肽抑制作用的BSO和具有铁还原特性的TA的促进下，BTF纳米颗粒可在肿瘤细胞中实现高氧化应激并随后导致细胞死亡。此外，BG纤维和VEGF均可促进组织再生并加速术后伤口愈合。这项工作中对肿瘤生长的同时抑制和组织修复的促进在术后肿瘤治疗和恢复领域具有启发性。
