Department of Preventive Dental Sciences, Department of Oral and Maxillofacial Surgery and Diagnostic Science, College of Dentistry, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Eur Rev Med Pharmacol Sci. 2023 Mar;27(5):1722-1728. doi: 10.26355/eurrev_202303_31532.
The aim of this study is to evaluate the effect of ten proinflammatory cytokines in GCF of participants with raised body mass index (BMI) compared to non-obese subjects undergoing fixed orthodontic treatment.
In the cross-sectional cohort, subjects were shortlisted through the purposive sampling method with the same age and gender and similar characteristics (cohort). For inclusion and exclusion, predefined criteria were followed. In all included participants obese and non-obese collection of GCF was made from mandibular canine to canine. Identification of inflammatory mediators (MPO and CRP) leptin, adiponectin, and resistin (pg/mL). Bone remodeling biomarkers RANKL (pg/mL) and tissue remodeling biomarkers MMP8, MMP9, TIMP1, and MMP8/TIMP1, MMP9/TIMP1 ratio were collected and blinded by the investigator. Normal distribution of data i.e., age, BMI, the flow rate of GCF, indices plaque and gingival, and uWMS were compared using a t-test. Non-normality biomarker data were evaluated using Mann-Whitney U-test. To assess the relationship between the concentration of GCF biomarkers and plaque and gingival indices Pearson and Spearman correlation coefficients were used.
The total number of participants included was 44. In the obese and non-obese groups, the male/female ratio was the same i.e., (n=11 each). The mean age of participants in the obese group was (25.7±1.55 years), whereas the non-obese group was (26.1±1.29 years). In obese the mean BMI was (33.6±2.1 kg/m2) whereas in non-obese (22.9±1.9 kg/m2) (p<0.02). Among the levels of biomarkers adiponectin (p<0.006) and leptin (p<0.028) demonstrated a significant difference between obese and non-obese participants. Also, a significant difference was noted between obese and non-obese in tissue remodeling biomarker MMP9 (p<0.03).
A surge in the level of the biomarkers, i.e., MMP9, leptin, and adiponectin in the gingival crevicular fluid is found in obese undergoing fixed orthodontic treatment.
本研究旨在评估与接受固定正畸治疗的非肥胖受试者相比，体质量指数（BMI）升高的受试者龈沟液（GCF）中 10 种促炎细胞因子的作用。
在横断面队列研究中，通过特定的抽样方法对具有相同年龄和性别以及相似特征（队列）的受试者进行筛选。根据预设标准纳入和排除患者。在所有纳入的患者中，收集了下颌尖牙至尖牙的 GCF 以鉴定炎症介质（MPO 和 CRP）、瘦素、脂联素和抵抗素（pg/mL）。收集骨改建生物标志物 RANKL（pg/mL）和组织改建生物标志物 MMP8、MMP9、TIMP1 和 MMP8/TIMP1、MMP9/TIMP1 比值，并由研究者进行盲法处理。使用 t 检验比较数据的正态分布，即年龄、BMI、GCF 流速、菌斑和牙龈指数以及 uWMS。使用 Mann-Whitney U 检验评估非正态分布生物标志物数据。使用 Pearson 和 Spearman 相关系数评估 GCF 生物标志物浓度与菌斑和牙龈指数之间的关系。
共纳入 44 名患者。在肥胖组和非肥胖组中，男女比例相同（n=11 例）。肥胖组患者的平均年龄为（25.7±1.55 岁），而非肥胖组为（26.1±1.29 岁）。肥胖组的平均 BMI 为（33.6±2.1 kg/m2），而非肥胖组为（22.9±1.9 kg/m2）（p<0.02）。在生物标志物中，脂联素（p<0.006）和瘦素（p<0.028）的水平在肥胖组和非肥胖组之间有显著差异。此外，在肥胖组和非肥胖组之间，组织改建生物标志物 MMP9 也有显著差异（p<0.03）。
在接受固定正畸治疗的肥胖患者中，发现龈沟液中生物标志物 MMP9、瘦素和脂联素水平升高。
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