Liu M, Deng W, Lu Y Y, He Y Z, Huang L Y, Du H
Department of Nerve Electrophysiology, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Eur Rev Med Pharmacol Sci. 2023 Mar;27(5):1831-1836. doi: 10.26355/eurrev_202303_31545.
Aside from the severity, surgical interventions for the treatment of neurological dysfunctions remain controversial. This study aimed to find factors predicting the benefits of tethered cord syndrome (TCS) surgery.
80 children with TCS were included and followed up for pre- and post-operative factors along with neurophysiological analysis. Outcomes were assessed by univariate and multivariate analysis.
Surgical treatment not only improved preoperative signs and symptoms in 79% of TCS patients but it showed to be an efficient procedure for the occurrence of future neurological defects. Univariate analysis also revealed that surgical intervention in TCS children (age <1 year) can modulate filar lipoma location and cutaneous abnormalities three months after surgery. Neurophysiological assessment revealed only 5.0% of surgical complications in TCS patients. Two patients had cerebrospinal fluid leakage, and two cases of CNS infection were detected.
Surgical intervention is highly recommended for the prevention of neurological deficits in children with TCS. Electrophysiological monitoring revealed rare complications following the surgery.
除了病情严重程度外，用于治疗神经功能障碍的手术干预仍存在争议。本研究旨在找出预测脊髓栓系综合征（TCS）手术疗效的因素。
纳入80例TCS患儿，对术前和术后因素以及神经生理学分析进行随访。通过单因素和多因素分析评估结果。
手术治疗不仅使79%的TCS患者术前症状体征得到改善，而且对未来神经功能缺损的发生显示出是一种有效的治疗方法。单因素分析还显示，对TCS患儿（年龄<1岁）进行手术干预可在术后三个月调节丝状脂肪瘤位置和皮肤异常。神经生理学评估显示TCS患者手术并发症仅为5.0%。2例患者出现脑脊液漏，检测到2例中枢神经系统感染。
强烈建议对TCS患儿进行手术干预以预防神经功能缺损。电生理监测显示术后并发症罕见。
