Department of Cardiology, Sakarya University School of Medicine, Sakarya, Turkey.
Eur Rev Med Pharmacol Sci. 2023 Mar;27(5):1881-1888. doi: 10.26355/eurrev_202303_31554.
Assessment of the monocyte-to-high-density lipoprotein ratio (MHR) is a new tool for predicting inflammation, which plays a major role in atherosclerosis. Subclavian artery stenosis (SAS) is usually asymptomatic, and atherosclerosis is the most common cause of chronic obstruction of the subclavian artery in adults. The aim of this study was to determine the relationship between the MHR and SAS.
Between January 2015 and January 2020, 43 patients with SAS and 43 patients without SAS were enrolled in the study. The patients' angiographic, demographic and clinic characteristics were reviewed from their medical records. Monocytes and HDL (high-density lipoprotein) cholesterols were measured through a complete blood count. The MHR was calculated as the ratio of the absolute monocyte count to the HDL cholesterol value. The resulting MHR values were divided into the following three groups: low (7.16 ± 1.59), moderate (11.08 ± 1.53) and high (21.70 ± 5.62). A p-value of less than 0.05 was considered significant.
MHR was found to be significantly higher in the SAS group compared to the control group with normal subclavian arteries (p<0.001). The frequency of SAS was found to increase with an increase in the MHR tertiles. Sensitivity and specificity values were 69.8% and 95.3%, respectively. The cut-off of the MHR value, taken as 13.39, was found to provide a significantly accurate prediction of the subclavian diagnosis (ROC area under the curve: 0.868, 95% CI: 0.789-0.947, p<0.001). After adjusting for other hematological parameters in the multivariate analysis, MHR (p=0.061) was found to be a predictor of the presence of SAS.
This study showed that MHR can be a convenient marker for predicting SAS because of the correlation between MHR and SAS.
单核细胞与高密度脂蛋白比值（MHR）的评估是一种新的炎症预测工具，炎症在动脉粥样硬化中起着重要作用。锁骨下动脉狭窄（SAS）通常无症状，而动脉粥样硬化是成人锁骨下动脉慢性阻塞的最常见原因。本研究旨在确定 MHR 与 SAS 之间的关系。
2015 年 1 月至 2020 年 1 月期间，共纳入 43 例 SAS 患者和 43 例无 SAS 患者。从病历中回顾患者的血管造影、人口统计学和临床特征。通过全血细胞计数测量单核细胞和高密度脂蛋白（HDL）胆固醇。MHR 通过绝对单核细胞计数与 HDL 胆固醇值的比值计算得出。将得到的 MHR 值分为以下三组：低（7.16±1.59）、中（11.08±1.53）和高（21.70±5.62）。p 值小于 0.05 被认为具有统计学意义。
与锁骨下动脉正常的对照组相比，SAS 组的 MHR 明显更高（p<0.001）。随着 MHR 三分位数的增加，SAS 的频率增加。敏感性和特异性值分别为 69.8%和 95.3%。MHR 值的截断值为 13.39，发现对锁骨下动脉诊断具有显著的准确性（ROC 曲线下面积：0.868，95%CI：0.789-0.947，p<0.001）。在多变量分析中，校正其他血液学参数后，MHR（p=0.061）被发现是 SAS 存在的预测因子。
本研究表明，MHR 可以作为预测 SAS 的一种方便的标志物，因为 MHR 与 SAS 之间存在相关性。
