难治性抗合成酶综合征中靶向CD19的嵌合抗原受体T细胞 - Suppr

CD19-targeted CAR T cells in refractory antisynthetase syndrome.

作者信息

Müller Fabian, Boeltz Sebastian, Knitza Johannes, Aigner Michael, Völkl Simon, Kharboutli Soraya, Reimann Hannah, Taubmann Jule, Kretschmann Sascha, Rösler Wolf, Manger Bernhard, Wacker Jochen, Mougiakakos Dimitrios, Jabari Samir, Schröder Rolf, Uder Michael, Roemer Frank, Krönke Gerhard, Mackensen Andreas, Schett Georg

机构信息

Department of Internal Medicine 5-Hematology and Oncology, Friedrich-Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen 91054, Germany; Deutsches Zentrum Immuntherapie, Friedrich-Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen 91054, Germany.

Deutsches Zentrum Immuntherapie, Friedrich-Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen 91054, Germany; Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen 91054, Germany.

出版信息

Lancet. 2023 Mar 11;401(10379):815-818. doi: 10.1016/S0140-6736(23)00023-5. Epub 2023 Feb 15.

DOI:10.1016/S0140-6736(23)00023-5

PMID:36930673

Abstract

摘要

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CD19-targeted CAR T cells in refractory antisynthetase syndrome.难治性抗合成酶综合征中靶向CD19的嵌合抗原受体T细胞

Lancet. 2023 Mar 11;401(10379):815-818. doi: 10.1016/S0140-6736(23)00023-5. Epub 2023 Feb 15.

Rescue therapy of antisynthetase syndrome with CD19-targeted CAR-T cells after failure of several B-cell depleting antibodies.在多种B细胞清除抗体治疗失败后，采用靶向CD19的嵌合抗原受体T细胞（CAR-T细胞）对合成酶综合征进行挽救治疗。

Rheumatology (Oxford). 2024 Jan 4;63(1):e12-e14. doi: 10.1093/rheumatology/kead330.

CD19-Targeting CAR T-Cell Therapy for Antisynthetase Syndrome.靶向CD19的嵌合抗原受体T细胞疗法治疗抗合成酶综合征

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Treatment of patients with relapsed or refractory CD19+ lymphoid disease with T lymphocytes transduced by RV-SFG.CD19.CD28.4-1BBzeta retroviral vector: a unicentre phase I/II clinical trial protocol.采用 RV-SFG.CD19.CD28.4-1BBzeta 逆转录病毒载体转导的 T 淋巴细胞治疗复发或难治性 CD19+淋巴组织疾病患者的单中心 I/II 期临床试验方案。

BMJ Open. 2019 May 19;9(5):e026644. doi: 10.1136/bmjopen-2018-026644.

[Application of CD19-CAR T Cells in Refractory Relapsed Acute B Lymphocyte Leukemia].CD19嵌合抗原受体T细胞在难治性复发急性B淋巴细胞白血病中的应用

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2018 Dec;26(6):1604-1609. doi: 10.7534/j.issn.1009-2137.2018.06.004.

[Efficacy and safety of CD19 chimeric antigen receptor T cells for the treatment of 22 patients with B-cell lymphoma].CD19嵌合抗原受体T细胞治疗22例B细胞淋巴瘤的疗效与安全性

Zhonghua Xue Ye Xue Za Zhi. 2019 Apr 14;40(4):276-280. doi: 10.3760/cma.j.issn.0253-2727.2019.04.003.

T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial.用于治疗儿童和青年急性淋巴细胞白血病的表达CD19嵌合抗原受体的T细胞：一项1期剂量递增试验

Lancet. 2015 Feb 7;385(9967):517-528. doi: 10.1016/S0140-6736(14)61403-3. Epub 2014 Oct 13.

Evidence of long-lasting anti-CD19 activity of engrafted CD19 chimeric antigen receptor-modified T cells in a phase I study targeting pediatrics with acute lymphoblastic leukemia.在一项针对小儿急性淋巴细胞白血病的 I 期研究中，证明了移植的嵌合抗原受体修饰的 CD19 特异性 T 细胞具有持久的抗 CD19 活性。

Hematol Oncol. 2019 Dec;37(5):601-608. doi: 10.1002/hon.2672. Epub 2019 Sep 15.

Beyond CD19 CAR-T cells in lymphoma.淋巴瘤中超越 CD19 CAR-T 细胞疗法。

Curr Opin Immunol. 2022 Feb;74:46-52. doi: 10.1016/j.coi.2021.09.009. Epub 2021 Nov 17.

Anti-CD19 chimeric antigen receptors T cells for the treatment of relapsed or refractory E2A-PBX1 positive acute lymphoblastic leukemia: report of three cases.抗 CD19 嵌合抗原受体 T 细胞治疗复发或难治性 E2A-PBX1 阳性急性淋巴细胞白血病：三例报告。

Leuk Lymphoma. 2019 Jun;60(6):1454-1461. doi: 10.1080/10428194.2018.1533127. Epub 2019 Feb 4.

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Indications for haematopoietic cell transplantation and CAR-T for haematological diseases, solid tumours and immune disorders: 2025 EBMT practice recommendations.造血细胞移植和嵌合抗原受体T细胞疗法治疗血液系统疾病、实体瘤及免疫紊乱的适应证：2025年欧洲血液与骨髓移植学会实践建议

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Successful Treatment of Diffuse Large B-Cell Lymphoma and Antisynthetase Syndrome with Bispecific Antibody Glofitamab.双特异性抗体戈利木单抗成功治疗弥漫性大B细胞淋巴瘤和抗合成酶综合征

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[Experiences after CD19-CAR T-cell therapy in non-SLE connective tissue diseases].[非系统性红斑狼疮结缔组织病患者接受CD19嵌合抗原受体T细胞疗法后的经验]

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CAR-T therapy: pioneering a new era in the treatment of autoimmune diseases.嵌合抗原受体T细胞（CAR-T）疗法：开创自身免疫性疾病治疗的新时代。

Front Immunol. 2025 Aug 13;16:1625166. doi: 10.3389/fimmu.2025.1625166. eCollection 2025.

CAR T-cell therapy in autoimmune diseases: a promising frontier on the horizon.自身免疫性疾病中的嵌合抗原受体T细胞疗法：一个充满前景的前沿领域。

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Chimeric Antigen Receptor T Cell Immunotherapy for Autoimmune Rheumatic Disorders: Where Are We Now?嵌合抗原受体T细胞免疫疗法治疗自身免疫性风湿性疾病：我们目前的进展如何？

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The next frontier in antibody-drug conjugates: challenges and opportunities in cancer and autoimmune therapy.抗体药物偶联物的下一个前沿领域：癌症与自身免疫疗法中的挑战与机遇

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Treatment of Immune-Mediated Necrotizing Myopathy.免疫介导性坏死性肌病的治疗

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Co-Occurrence of Anti-Synthetase Syndrome and Sjögren Disease: A Case-Based Review.抗合成酶综合征与干燥综合征的共病：基于病例的综述。

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