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Irreconcilable Differences: The Divorce Between Response Rates, Progression-Free Survival, and Overall Survival.

作者信息

Merino Margret, Kasamon Yvette, Theoret Marc, Pazdur Richard, Kluetz Paul, Gormley Nicole

机构信息

Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD.

Oncology Center of Excellence, US Food and Drug Administration, Silver Spring, MD.

出版信息

J Clin Oncol. 2023 May 20;41(15):2706-2712. doi: 10.1200/JCO.23.00225. Epub 2023 Mar 17.

DOI:10.1200/JCO.23.00225
PMID:36930853
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10414695/
Abstract
摘要

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Irreconcilable Differences: The Divorce Between Response Rates, Progression-Free Survival, and Overall Survival.不可调和的差异：缓解率、无进展生存期和总生存期之间的脱节
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The saga of PI3K inhibitors in haematological malignancies: survival is the ultimate safety endpoint.血液系统恶性肿瘤中PI3K抑制剂的传奇故事：生存是最终的安全性终点。
Lancet Oncol. 2022 May;23(5):563-566. doi: 10.1016/S1470-2045(22)00200-5. Epub 2022 Apr 14.
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Rucaparib versus standard-of-care chemotherapy in patients with relapsed ovarian cancer and a deleterious BRCA1 or BRCA2 mutation (ARIEL4): an international, open-label, randomised, phase 3 trial.鲁卡帕利与标准护理化疗用于复发性卵巢癌且携带有害 BRCA1 或 BRCA2 突变患者的对比（ARIEL4）：一项国际性、开放性标签、随机、3 期临床试验。
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