Department of Pathobiology, Auburn University College of Veterinary Medicine, Auburn, Alabama, USA.
Charlotte Animal Referral & Emergency, Charlotte, North Carolina, USA.
J Comp Pathol. 2023 Apr;202:1-4. doi: 10.1016/j.jcpa.2023.02.001. Epub 2023 Mar 15.
A 12-year-old male neutered Australian Shepherd Dog was presented to Charlotte Animal Referral & Emergency with a history of a thoracic mass. On physical examination, physiological parameters were within the normal ranges, and a complete haemogram and serum biochemistry profile were unremarkable except for mild thrombocytopenia. A computed tomography scan revealed a 21 × 15 × 12.7 cm thoracic mass encompassing the cranial mediastinum and extending to the right caudal thorax. The mass was surgically removed and histopathological evaluation revealed that it comprised remnants of the thymus and a neoplasm composed of large blood-filled vascular spaces lined by a single layer of endothelial cells with mild anisocytosis and anisokaryosis. The neoplastic cells had diffuse strong immunolabeling for endothelial cell marker CD31. Multifocally, there were large cystic degenerated areas of thymic tissue lined by plump cytokeratin AE1/AE3-positive epithelial cells. Based on these findings, a diagnosis of thymic cavernous haemangioma (CH) was made. Thymic CH is rare in animals, with the only reported case in a cross bred cow. To our knowledge, this is the first case of a thymic CH in a dog.
一只 12 岁雄性去势澳大利亚牧羊犬因胸部肿块被带到夏洛特动物转诊和急救中心就诊。体格检查时，生理参数在正常范围内，全血细胞计数和血清生化分析也无明显异常，仅存在轻度血小板减少症。计算机断层扫描显示一个 21×15×12.7 厘米的胸部肿块，包含颅纵隔并延伸到右侧胸后部。该肿块被手术切除，组织病理学评估显示它由胸腺残余物和由充满血液的大血管腔组成的肿瘤组成，由单层内皮细胞排列，具有轻微的异形性和核多形性。肿瘤细胞弥漫性强烈免疫标记内皮细胞标志物 CD31。多处可见由饱满的细胞角蛋白 AE1/AE3 阳性上皮细胞排列的胸腺组织囊性退行性大区域。根据这些发现，诊断为胸腺海绵状血管瘤（CH）。在动物中，胸腺 CH 非常罕见，仅在杂交奶牛中有过一例报道。据我们所知，这是犬胸腺 CH 的首例病例。
