采用 UHPLC-MS/MS 分段分析测定头发中的 5 种合成大麻素及其在 8 例多药滥用案例中的应用。
Determination of 5 synthetic cannabinoids in hair by Segmental analysis using UHPLC-MS/MS and its application to eight polydrug abuse cases.
机构信息
Department of Forensic Toxicology, Academy of Forensic Science, Shanghai Key Laboratory of Forensic Medicine, Shanghai 200063, China.
Department of Forensic Toxicology, Academy of Forensic Science, Shanghai Key Laboratory of Forensic Medicine, Shanghai 200063, China; Department of Forensic Medicine of Shanghai Medical College, Fudan University, 138 Medical College Road, Shanghai 200433, China.
出版信息
Forensic Sci Int. 2023 May;346:111611. doi: 10.1016/j.forsciint.2023.111611. Epub 2023 Feb 28.
In recent years, an increasing number of new synthetic cannabinoids (SCs) have appeared in the drug trade market. A UPLC-MS/MS method was developed to simultaneously identify five synthetic cannabinoids in 1 cm segment hair samples. The method was fully validated and confirmed to have good selectivity, accuracy, and precision, as well as satisfactory linearity within the calibrated range. The limit of quantification (LOD) was 0.5 pg/mg, and the lower limit of quantitation (LLOQ) was 1 pg/mg, with intraday and interday accuracies (bias) ranging from - 9.6-13.7%. The validated method was successfully used for qualitative and quantitative analysis of five SCs in authentic hair samples of eight SC abusers. SCs were detected in 8 cases at concentrations ranging from 1.5 to 632.9 pg/mg.
近年来，越来越多的新型合成大麻素（SCs）出现在毒品交易市场。本研究建立了 UPLC-MS/MS 方法，用于对 1cm 毛发段样品中 5 种合成大麻素进行同时定性定量分析。该方法具有良好的选择性、准确性和精密度，在校准范围内线性关系良好。定量下限（LLOQ）为 1pg/mg，检出限（LOD）为 0.5pg/mg，日内和日间准确度（偏差）在-9.6%-13.7%范围内。该方法已成功应用于 8 例 SC 滥用者的真实毛发样品中 5 种 SC 的定性和定量分析。8 例样品中均检测到 SC，浓度范围为 1.5-632.9pg/mg。
Zotero 插件