Unidad de Lípidos y Arteriosclerosis, Hospital Universitario Reina Sofía/Universidad de Córdoba/Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, España; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, España.
CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, España; Unidad de Lípidos, Servicio de Endocrinología y Nutrición, Instituto de Investigaciones Biomédicas August Pi i Sunyer, Barcelona, Hospital Clinic, Universidad de Barcelona, Barcelona, España.
Clin Investig Arterioscler. 2023 Sep-Oct;35(5):248-261. doi: 10.1016/j.arteri.2023.02.002. Epub 2023 Mar 15.
In the management of hypercholesterolemia, besides advising a healthy, plant-based diet, it may be useful to recommend functional foods or nutraceutical with cholesterol-lowering properties. Given the progressive increase in the number of these products and their rising use by the population, the Spanish Society of Arteriosclerosis (SEA) has considered it appropriate to review the available information, select the results of the scientifically more robust studies and take a position on their usefulness, to recommend to health professionals and the general population their potential utility in terms of efficacy and their possible benefits and limitations. The following clinical scenarios have been identified in which these products could be used and will be analyzed in more detail in this document: (1) Hypolipidemic treatment in subjects with statin intolerance. (2) Hypolipidemic treatment «a la carte» in individuals in primary prevention. (3) Long-term cardiovascular prevention in individuals with no indication for lipid-lowering therapy. (4) Patients with optimized lipid-lowering treatment who do not achieve therapeutic objectives.
在治疗高胆固醇血症方面，除了建议采用健康的植物性饮食外，推荐具有降胆固醇特性的功能性食品或营养保健品可能也会有所帮助。鉴于这些产品的数量不断增加，且越来越多的人群在使用，西班牙动脉粥样硬化学会（SEA）认为，有必要对现有信息进行审查，选择科学上更可靠的研究结果，并对其有效性和可能的益处和局限性发表看法，以便向卫生专业人员和一般人群推荐其在疗效方面的潜在效用。本文件将详细分析以下临床情况下可能使用这些产品：（1）他汀类药物不耐受患者的降脂治疗。（2）一级预防个体的降脂治疗“点菜式”。（3）无降脂治疗指征个体的长期心血管预防。（4）已接受优化降脂治疗但未达到治疗目标的患者。
