Desplanches D, Mayet M H, Semporé B, Frutoso J, Flandrois R
Unité Associée 0621, Centre National de la Recherche Scientifique, Laboratoire de Physiologie, Faculté de Médecine Grange-Blanche, Université Claude Bernard (Lyon I), France.
J Appl Physiol (1985). 1987 Nov;63(5):1739-43. doi: 10.1152/jappl.1987.63.5.1739.
The purpose of this study was to compare the effects of spontaneous recovery or recovery by treadmill training (180 min/day, 5 days/wk, 30 m/min for 8 wk) on maximal O2 uptake (VO2max), histochemical and biochemical muscular properties (soleus), of rats subsequent to 5 wk of hindlimb suspension. Spontaneous recovery reversed the 15% reduction in VO2max, whereas training posthypokinesia induced a 20% increase over control values. In the spontaneous recovery group, both citrate synthase and 3-hydroxyacyl-CoA dehydrogenase activities, decreased by hypokinesia (-40%), increased but remained 20% below the control level. In the training posthypokinesia group, an increase of these activities over control occurred (+50 and +20%, respectively). Recovery or training led to a 100% type I distribution in soleus muscle and to a recovery of all fibers' cross-sectional areas. In the spontaneous recovery group, capillaries per fiber, decreased by 46%, returned to the normal range. In the training posthypokinesia group, training induced an increase in capillaries per fiber above their control values (+23%). These results point to the plasticity of the muscle and indicate the necessity of a posthypokinesia training program for recovery of the total oxidative enzyme capacity.
本研究的目的是比较自发性恢复或跑步机训练（每天180分钟，每周5天，速度30米/分钟，持续8周）对后肢悬吊5周后的大鼠最大摄氧量（VO2max）、比目鱼肌的组织化学和生物化学肌肉特性的影响。自发性恢复逆转了VO2max降低15%的情况，而后运动减退后训练使VO2max比对照值增加了20%。在自发性恢复组中，柠檬酸合酶和3-羟酰基辅酶A脱氢酶的活性，因运动减退而降低（-40%），虽有所增加但仍比对照水平低20%。在运动减退后训练组中，这些活性相对于对照有所增加（分别增加了50%和20%）。恢复或训练使比目鱼肌中I型纤维分布达到100%，且所有纤维的横截面积都得以恢复。在自发性恢复组中，每根纤维的毛细血管数量减少了46%，恢复到正常范围。在运动减退后训练组中，训练使每根纤维的毛细血管数量增加至高于对照值（增加了23%）。这些结果表明了肌肉的可塑性，并指出运动减退后训练计划对于恢复总氧化酶能力的必要性。
