Unidad de Investigación Biomédica, Delegación Durango, Instituto Mexicano del Seguro Social, Predio Canoas 100, Col. Los Angeles, 34077, Durango, Dgo., Mexico.
Endocrinology Division, Facultad de Medicina, Hospital Universitario "Dr. José E. González", Universidad Autónoma de Nuevo León, Monterrey, NL, México.
Eur J Pediatr. 2023 Jun;182(6):2559-2565. doi: 10.1007/s00431-023-04935-z. Epub 2023 Mar 18.
The aim of this study was to compare the association of the triglycerides and glucose (TyG) index and homeostatic model assessment of insulin resistance (HOMA-IR) with lipoprotein(a) (lp[a]), apolipoprotein AI (apoAI), and apoliprotein B (apoB) concentrations in children with normal-weight. Children with normal weight aged 6-10 years and Tanner 1 stage were included in a cross-sectional study. Underweight, overweight, obesity, smoking, alcohol intake, pregnancy, acute or chronic illnesses, and any kind of pharmacological treatment were exclusion criteria. According to the lp(a) levels, children were allocated into the groups with elevated concentrations and normal values. A total of 181 children with normal weight and an average age of 8.4 ± 1.4 years were enrolled in the study. The TyG index showed a positive correlation with lp(a) and apoB in the overall population (r = 0.161 and r = 0.351, respectively) and boys (r = 0.320 and r = 0.401, respectively), but only with apoB in the girls (r = 0.294); while the HOMA-IR had a positive correlation with lp(a) levels in the overall population (r = 0.213) and boys (r = 0.328). The linear regression analysis showed that the TyG index is associated with lp(a) and apoB in the overall population (B = 20.72; 95%CI 2.03-39.41 and B = 27.25; 95%CI 16.51-37.98, respectively) and boys (B = 40.19; 95%CI 14.50-65.7 and B = 29.60; 95%CI 15.03-44.17, respectively), but only with apoB in the girls (B = 24.22; 95%CI 7.90-40.53). The HOMA-IR is associated with lp(a) in the overall population (B = 5.37; 95%CI 1.74-9.00) and boys (B = 9.63; 95%CI 3.65-15.61). Conclusion: The TyG index is associated with both lp(a) and apoB in children with normal-weight. What is Known: • The triglycerides and glucose index has been positively associated with an increased risk of cardiovascular disease in adults. What is New: • The triglycerides and glucose index is strongly associated with lipoprotein(a) and apolipoprotein B in children with normal-weight. • The triglycerides and glucose index may be a useful tool to identify cardiovascular risk in children with normal-weight.
本研究旨在比较甘油三酯和葡萄糖（TyG）指数与稳态模型评估的胰岛素抵抗（HOMA-IR）与脂蛋白（a）（lp[a]）、载脂蛋白 AI（apoAI）和载脂蛋白 B（apoB）在正常体重儿童中的关联。纳入了年龄在 6-10 岁且处于 Tanner 1 期的正常体重儿童进行横断面研究。排除标准为体重不足、超重、肥胖、吸烟、饮酒、怀孕、急性或慢性疾病以及任何形式的药物治疗。根据 lp(a)水平，将儿童分为 lp(a)浓度升高组和正常组。共有 181 名正常体重且平均年龄为 8.4±1.4 岁的儿童被纳入本研究。在总体人群（r=0.161 和 r=0.351）和男孩（r=0.320 和 r=0.401）中，TyG 指数与 lp(a)和 apoB 呈正相关，但仅在女孩中与 apoB 呈正相关（r=0.294）；而 HOMA-IR 与总体人群（r=0.213）和男孩（r=0.328）的 lp(a)水平呈正相关。线性回归分析显示，TyG 指数与总体人群（B=20.72；95%CI 2.03-39.41 和 B=27.25；95%CI 16.51-37.98）和男孩（B=40.19；95%CI 14.50-65.7 和 B=29.60；95%CI 15.03-44.17）中的 lp(a)和 apoB 相关，但仅在女孩中与 apoB 相关（B=24.22；95%CI 7.90-40.53）。HOMA-IR 与总体人群（B=5.37；95%CI 1.74-9.00）和男孩（B=9.63；95%CI 3.65-15.61）中的 lp(a)相关。结论：TyG 指数与正常体重儿童的 lp(a)和 apoB 均相关。已知内容：•甘油三酯和葡萄糖指数与成年人心血管疾病风险增加呈正相关。新发现：•甘油三酯和葡萄糖指数与正常体重儿童的脂蛋白（a）和载脂蛋白 B 密切相关。•甘油三酯和葡萄糖指数可能是识别正常体重儿童心血管风险的有用工具。
