阴茎癌患者的腹股沟淋巴结清扫术：多中心环境下开放手术与视频内镜手术方法的比较
Inguinal lymphadenectomy in penile cancer patients: a comparison between open and video endoscopic approach in a multicenter setting.
作者信息
Bada Maida, Crocetto Felice, Nyirady Peter, Pagliarulo Vincenzo, Rapisarda Sebastiano, Aliberti Antonio, Boccasile Stefano, Ferro Matteo, Barone Biagio, Celia Antonio
机构信息
Department of Urology, San Bassanino Hospital, Bassano del Grappa, Vicenza, Italy.
Department of Neurosciences, Reproductive Sciences and Odontostomatology - Federico II University of Naples, Naples, Italy.
出版信息
J Basic Clin Physiol Pharmacol. 2023 Mar 20;34(3):383-389. doi: 10.1515/jbcpp-2023-0038. eCollection 2023 May 1.
OBJECTIVES
To compare differences of operative outcomes, post-operative complications and survival outcomes between open and laparoscopic cases in a multicenter study.
METHODS
This was a retrospective cohort study performed at three European centers from September 2011 to January 2019. The surgeon decision to perform open inguinal lymphadenectomy (OIL) or video endoscopic inguinal lymphadenectomy (VEIL) was done in each hospital after patient counselling. Inclusion criteria regarded a minimum follow-up of 9 months since the inguinal lymphadenectomy.
RESULTS
A total of 55 patients with proven squamous cell penile cancer underwent inguinal lymphadenectomy. 26 of them underwent OIL, while 29 patients underwent VEIL. For the OIL and VEIL groups, the mean operative time was 2.5 vs. 3.4 h (p=0.129), respectively. Hospital stays were lower in the VEIL group with 4 vs. 8 days in OIL patients (p=0.053) while number of days requiring drains to remain was 3 vs. 6 days (p=0.024). The VEIL group reported a lower incidence of major complications compared to the OIL group (2 vs. 17%, p=0.0067) while minor complications were comparable in both groups. In a median follow-up period of 60 months, the overall survival was 65.5 and 84.6% in OIL and VEIL groups, respectively (p=0.105).
CONCLUSIONS
VEIL is comparable to OIL regarding safety, overall survival and post-operative outcomes.
目的
在一项多中心研究中比较开放手术与腹腔镜手术病例的手术结果、术后并发症及生存结果的差异。
方法
这是一项回顾性队列研究，于2011年9月至2019年1月在三个欧洲中心进行。在每家医院，经患者咨询后，由外科医生决定进行开放性腹股沟淋巴结清扫术（OIL）或视频内镜腹股沟淋巴结清扫术（VEIL）。纳入标准为自腹股沟淋巴结清扫术后至少随访9个月。
结果
共有55例经证实的阴茎鳞状细胞癌患者接受了腹股沟淋巴结清扫术。其中26例接受了OIL，29例接受了VEIL。OIL组和VEIL组的平均手术时间分别为2.5小时和3.4小时（p = 0.129）。VEIL组的住院时间较短（4天，而OIL组患者为8天，p = 0.053），引流管留置天数为3天和6天（p = 0.024）。与OIL组相比，VEIL组报告的主要并发症发生率较低（2%对17%，p = 0.0067），而两组的轻微并发症相当。在中位随访期60个月时，OIL组和VEIL组的总生存率分别为65.5%和84.6%（p = 0.105）。
结论
在安全性、总生存率和术后结果方面，VEIL与OIL相当。
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