Liu Jie, Yan Qin, Wang Li-Xia, He Xiao-Ping, Hu Hong, Liu Yan-Chun, Li Dan, Liu Yan, Guo Kai, Li Sheng-Hong
State Key Laboratory of Southwestern Chinese Medicine Resources, And Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, PR China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, And Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, PR China.
Phytochemistry. 2023 Jun;210:113642. doi: 10.1016/j.phytochem.2023.113642. Epub 2023 Mar 17.
Detailed phytochemical investigation on the traditional Chinese medicine Swertia pseudochinensis Hara led to the isolation of ten undescribed secoiridoids and fifteen known analogs. Their structures were elucidated by extensive spectroscopic analysis (including 1D and 2D NMR, and HRESIMS). Selected isolates were assayed for their anti-inflammatory and antibacterial activities, and moderate anti-inflammatory activity via inhibiting the secretion of cytokines IL-6 and TNF-α in macrophages RAW264.7 induced by LPS were observed. Antibacterial activity against Staphylococcus aureus was not found at 100 μM.
对中药当药（Swertia pseudochinensis Hara）进行了详细的植物化学研究，从中分离出10个未描述的裂环环烯醚萜类化合物和15个已知类似物。通过广泛的光谱分析（包括一维和二维核磁共振以及高分辨电喷雾电离质谱）阐明了它们的结构。对选定的分离物进行了抗炎和抗菌活性测定，观察到其具有适度的抗炎活性，即通过抑制脂多糖诱导的巨噬细胞RAW264.7中细胞因子IL-6和TNF-α的分泌来实现。在100μM浓度下未发现对金黄色葡萄球菌的抗菌活性。
