核仁 DNA 损伤检查点反应的分子机制。
Molecular mechanisms of nucleolar DNA damage checkpoint response.
机构信息
Department of Biological Sciences, University of North Carolina at Charlotte, Charlotte, NC 28223, USA.
Department of Biological Sciences, University of North Carolina at Charlotte, Charlotte, NC 28223, USA; Center for Biomedical Engineering and Science, University of North Carolina at Charlotte, Charlotte, NC 28223, USA; School of Data Science, University of North Carolina at Charlotte, Charlotte, NC 28223, USA.
出版信息
Trends Cell Biol. 2023 May;33(5):361-364. doi: 10.1016/j.tcb.2023.02.003. Epub 2023 Mar 16.
Abstract
Ribosomal DNA (rDNA) is transcribed into RNA in the nucleolus and is often challenged by different stress conditions. However, the underlying mechanisms of nucleolar DNA damage response (DDR) pathways remain elusive. Here, we provide distinct perspectives on how nucleolar DDR checkpoint pathways are activated by different stresses or by liquid-liquid phase separation (LLPS).
摘要
核糖体 DNA(rDNA) 在核仁中被转录为 RNA，并经常受到不同应激条件的挑战。然而，核仁 DNA 损伤反应 (DDR) 途径的潜在机制仍不清楚。在这里，我们提供了不同的观点，说明核仁 DDR 检查点途径如何被不同的应激或液-液相分离 (LLPS) 激活。
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