Aoyama Shintaro, Okuda Hiroto, Furuzawa Natsu, Yoneda Hirokage, Fujikane Daisuke, Takai Kentaro, Kuramitsu Ayumi, Muto Yukimasa, Sugiyama Shunsuke, Shioiri Toshiki, Ohi Kazutaka
School of Medicine, Gifu University, Gifu, Japan.
Department of Psychiatry, Gifu University Graduate School of Medicine, Gifu, Japan.
Schizophrenia (Heidelb). 2023 Mar 18;9(1):16. doi: 10.1038/s41537-023-00345-0.
Patients with schizophrenia (SZ) display moderate reductions in brainstem volumes, including the midbrain, pons, superior cerebellar peduncle, and medulla oblongata. Here, we investigated alterations in brainstem volumes between SZ patients and healthy controls (HCs) stratified by sex. T1-weighted MRI brain scans were processed with FreeSurfer v6.0 in 156 SZ patients (61 males/95 females) and 205 HCs (133/72). Of the brainstem structures, pons volumes were significantly reduced, particularly in male SZ patients. The decreased pons volumes were correlated with lower levels of education but not duration of illness in male patients. These findings suggest that the reduction in pons volume in male patients might be occurred before or around the onset of the disorder.
精神分裂症（SZ）患者的脑干体积会出现中度减小，包括中脑、脑桥、小脑上脚和延髓。在此，我们研究了按性别分层的SZ患者与健康对照者（HCs）之间脑干体积的变化。对156例SZ患者（61例男性/95例女性）和205例HCs（133例/72例）的T1加权MRI脑部扫描图像使用FreeSurfer v6.0进行处理。在脑干结构中，脑桥体积显著减小，尤其是男性SZ患者。男性患者脑桥体积减小与受教育程度较低有关，但与病程无关。这些发现表明，男性患者脑桥体积的减小可能发生在疾病发作之前或发作前后。
