Sullivan Edith V, Rosenbloom Margaret, Serventi Kathleen L, Pfefferbaum Adolf
Department of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Neurobiol Aging. 2004 Feb;25(2):185-92. doi: 10.1016/s0197-4580(03)00044-7.
Volumes of thalamus, pons, cortical gray matter, and white matter were derived from MR brain images of healthy men and women spanning the adult age range in order to delineate patterns of aging and to compare age and sex effects in thalamus and pons with such effects in cortical gray and white matter volumes. Men had larger intracranial volume (ICV) than women, but ICV did not correlate with age in either sex. Thalamic, pontine, and cortical white matter volumes did not differ between men and women once ICV differences were taken into account, but men had more cortical gray matter than women even after accounting for ICV. Volumes of pons and thalamus were associated, independent of ICV, in women but not in men. Thalamic volume declined linearly with age at a similar rate in both men and women, whereas cortical gray matter volume declined more steeply with age in men than women. Both pontine and cortical white matter volumes remained stable across the age span in both men and women.
为了描绘衰老模式，并比较丘脑和脑桥的年龄及性别效应与皮质灰质和白质体积的此类效应，我们从成年年龄范围内的健康男性和女性的脑部磁共振成像（MR）中得出了丘脑、脑桥、皮质灰质和白质的体积。男性的颅内体积（ICV）大于女性，但ICV在两性中均与年龄无关。一旦考虑到ICV差异，丘脑、脑桥和皮质白质体积在男性和女性之间并无差异，但即使在考虑ICV之后，男性的皮质灰质仍比女性多。在女性中，独立于ICV之外，脑桥和丘脑的体积相关，但在男性中并非如此。丘脑体积在男性和女性中均以相似的速率随年龄呈线性下降，而男性皮质灰质体积随年龄下降的幅度比女性更陡。男性和女性的脑桥和皮质白质体积在整个年龄范围内均保持稳定。
