Ma Yingying, Cong Zhufeng, Gao Peng, Wang Yancai
College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China; School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, P R China.
College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
Eur J Pharm Sci. 2023 Jun 1;185:106425. doi: 10.1016/j.ejps.2023.106425. Epub 2023 Mar 18.
The drug nanosuspensions is a universal formulation approach for improved drug delivery of hydrophobic drugs and one the most promising approaches for increasing the biopharmaceutical performance of poorly water-soluble drug substances, especially for nature products. This review aimed to summarize the nanosuspensions preparation approaches and the main technological difficulties encountered in nanosuspensions development, such as guidelines for stabilizers screening, in vivo fate of the intravenously administrated nanosuspensions, and how to realize the intravenously target delivery was reviewed. Furthermore, challenges of nanosuspensions for the nature products delivery also was discussed and commented. Therefore, it hoped to provide reference and assistance for the nanosuspensions production, stabilizers usage, and predictability of in vivo fate and controllability of targeting delivery of the nature products nanosuspensions.
药物纳米混悬液是一种用于改善疏水性药物给药的通用制剂方法，也是提高难溶性药物生物制药性能最具前景的方法之一，尤其是对于天然产物。本综述旨在总结纳米混悬液的制备方法以及纳米混悬液开发过程中遇到的主要技术难题，如稳定剂筛选指南、静脉注射纳米混悬液的体内命运，以及如何实现静脉靶向给药等内容进行了综述。此外，还对纳米混悬液用于天然产物递送的挑战进行了讨论和评论。因此，希望能为天然产物纳米混悬液的生产、稳定剂使用、体内命运的可预测性以及靶向递送的可控性提供参考和帮助。
