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天然产物作为炎症性疾病治疗剂的潜力。

Potential of Natural Products as Therapeutic Agents for Inflammatory Diseases.

机构信息

Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Waghodia, Vadodara-391760, Gujarat, India.

出版信息

Antiinflamm Antiallergy Agents Med Chem. 2024;23(3):149-163. doi: 10.2174/0118715230307969240614102321.

DOI:10.2174/0118715230307969240614102321
PMID:38984571
Abstract

Inflammation is a complex biological response that plays a pivotal role in various pathological conditions, including inflammatory diseases. The search for effective therapeutic agents has led researchers to explore natural products due to their diverse chemical composition and potential therapeutic benefits. This review comprehensively examines the current state of research on natural products as potential therapeutic agents for inflammatory diseases. The article discusses the antiinflammatory properties of various natural compounds, their mechanisms of action, and their potential applications in managing inflammatory disorders. Additionally, formulation and delivery systems, challenges and future prospects in this field are also highlighted.

摘要

炎症是一种复杂的生物反应,在各种病理条件中起着关键作用,包括炎症性疾病。由于天然产物具有多样的化学组成和潜在的治疗益处,寻找有效的治疗剂促使研究人员对其展开了探索。本综述全面考察了天然产物作为炎症性疾病潜在治疗剂的研究现状。文章讨论了各种天然化合物的抗炎特性、它们的作用机制,以及它们在管理炎症性疾病方面的潜在应用。此外,还强调了该领域的制剂和给药系统、挑战和未来前景。

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Potential of Natural Products as Therapeutic Agents for Inflammatory Diseases.天然产物作为炎症性疾病治疗剂的潜力。
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本文引用的文献

1
Algae-Derived Natural Products in Diabetes and Its Complications-Current Advances and Future Prospects.糖尿病及其并发症中源自藻类的天然产物——当前进展与未来展望
Life (Basel). 2023 Aug 29;13(9):1831. doi: 10.3390/life13091831.
2
Lipid-Based Delivery Systems for Flavonoids and Flavonolignans: Liposomes, Nanoemulsions, and Solid Lipid Nanoparticles.用于黄酮类化合物和黄酮木脂素的脂质递送系统:脂质体、纳米乳液和固体脂质纳米粒。
Pharmaceutics. 2023 Jul 14;15(7):1944. doi: 10.3390/pharmaceutics15071944.
3
Nanosuspensions technology as a master key for nature products drug delivery and In vivo fate.
纳米混悬液技术作为天然产物药物递送及体内命运的关键技术。
Eur J Pharm Sci. 2023 Jun 1;185:106425. doi: 10.1016/j.ejps.2023.106425. Epub 2023 Mar 18.
4
Past, Present and (Foreseeable) Future of Biological Anti-TNF Alpha Therapy.生物抗 TNF-α 疗法的过去、现在及(可预见的)未来
J Clin Med. 2023 Feb 17;12(4):1630. doi: 10.3390/jcm12041630.
5
Solid lipid nanoparticles and nanostructured lipid carriers: a review of the methods of manufacture and routes of administration.固体脂质纳米粒和纳米结构脂质载体:制备方法和给药途径的综述。
Pharm Dev Technol. 2022 Jun;27(5):525-544. doi: 10.1080/10837450.2022.2084554. Epub 2022 Jul 14.
6
Chronic Inflammation in Non-Healing Skin Wounds and Promising Natural Bioactive Compounds Treatment.慢性炎症在非愈合皮肤伤口及有前景的天然生物活性化合物治疗中的作用
Int J Mol Sci. 2022 Apr 28;23(9):4928. doi: 10.3390/ijms23094928.
7
The role of plant-derived natural antioxidants in reduction of oxidative stress.植物源性天然抗氧化剂在减轻氧化应激中的作用。
Biofactors. 2022 May;48(3):611-633. doi: 10.1002/biof.1831. Epub 2022 Mar 1.
8
From NSAIDs to Glucocorticoids and Beyond.从 NSAIDs 到糖皮质激素,以及更多。
Cells. 2021 Dec 14;10(12):3524. doi: 10.3390/cells10123524.
9
Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities.代谢组学和基因组学在天然产物研究中的应用:靶向新化学实体的互补工具。
Nat Prod Rep. 2021 Nov 17;38(11):2041-2065. doi: 10.1039/d1np00036e.
10
Targeting Mammalian 5-Lipoxygenase by Dietary Phenolics as an Anti-Inflammatory Mechanism: A Systematic Review.靶向膳食酚类物质的哺乳动物 5-脂氧合酶作为一种抗炎机制:系统评价。
Int J Mol Sci. 2021 Jul 25;22(15):7937. doi: 10.3390/ijms22157937.