Research Lab. of Laboratory Animals, Research Center for Laboratory Animals, Comprehensive Research Facilities for Advanced Medical Science, School of Medicine, Dokkyo Medical University, Tochigi 321-0293, Japan.
J Reprod Dev. 2023 Jun 6;69(3):147-153. doi: 10.1262/jrd.2022-114. Epub 2023 Mar 18.
Progesterone (P) enhances spermatozoal hyperactivation, a capacitation event. Hyperactivation is associated with successful in vitro fertilization (IVF). In this study, we examined the effects of P on hyperactivation and IVF in mice. P enhanced spermatozoal hyperactivation and increased IVF success rate in a dose-dependent manner. Moreover, P affected spermatozoal hyperactivation and IVF through the membrane progesterone receptor of the spermatozoal head. These results show that P regulates spermatozoal capacitation and fertilization in mice. The concentration of P changes during the estrous cycle, indicating that spermatozoa are capacitated in response to the oviductal environment and subsequently fertilize the oocyte.
孕激素（P）增强了精子的超激活，这是一种获能事件。超激活与体外受精（IVF）的成功有关。在这项研究中，我们研究了 P 对小鼠精子超激活和 IVF 的影响。P 以剂量依赖的方式增强精子的超激活并提高 IVF 的成功率。此外，P 通过精子头部的膜孕激素受体影响精子的超激活和 IVF。这些结果表明，P 调节小鼠精子的获能和受精。孕激素的浓度在发情周期中发生变化，这表明精子在响应输卵管环境后获能，并随后使卵子受精。
