Yrivarren J L, Lopez L R
Department of Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru.
J Clin Immunol. 1987 Nov;7(6):471-4. doi: 10.1007/BF00915057.
We report the occurrence of cryoglobulinemia and cutaneous vasculitis in three patients with brucellosis caused by Brucella melitensis. The isolated cryoglobulins were characterized as mixed polyclonal or type III. Brucella agglutinin activity was not detected in any of the cryoglobulins analyzed. However, the same agglutinin titer and the presence of precipitin lines of identity in immunodiffusion gels were observed in the supernatant of the cryoglobulins and the serum. Rheumatoid-factor activity was present in all the cryoprecipitates tested. Resolution of the purpuric lesions with therapy coincided with a decrease in serum cryoglobulins and, in one patient, with normalization of his serum C3 levels. These findings suggest that the immunological abnormalities manifested by our patients were the direct consequence of the brucellosis infection and provide additional evidence to support the role for immunological mechanisms in the pathogenesis of human brucellosis.
我们报告了3例由羊布鲁氏菌引起的布鲁氏菌病患者出现冷球蛋白血症和皮肤血管炎的情况。分离出的冷球蛋白被鉴定为混合多克隆型或III型。在所分析的任何冷球蛋白中均未检测到布鲁氏菌凝集素活性。然而，在冷球蛋白的上清液和血清中观察到相同的凝集素滴度以及免疫扩散凝胶中存在相同的沉淀线。在所有检测的冷沉淀物中均存在类风湿因子活性。治疗后紫癜性病变的消退与血清冷球蛋白的减少相一致，在1例患者中，血清C3水平恢复正常。这些发现表明，我们的患者所表现出的免疫异常是布鲁氏菌病感染的直接后果，并为支持免疫机制在人类布鲁氏菌病发病机制中的作用提供了额外证据。
