Cannat A, Escande A, Peraldi F, Serre A
Ann Immunol (Paris). 1983 Jan-Feb;134C(1):43-53. doi: 10.1016/s0769-2625(83)80152-4.
"PI", a vaccinating fraction with B mitogenic and polyclonal activator (PCA) activity extracted from Brucella melitensis, was i. p. injected into B6 and DB mice. In B6 mice, this led to an important but transient increase in the level of anti-ssDNA antibodies, the induction of rheumatoid factor (RF) and the appearance of circulating immune complexes (CIC). In DB mice, on the other hand, the only significant effect consisted of a slight and ephemeral peak of CIC in sera from day 7. Similarly, while i. v. inoculation of live B. suis did not influence the levels of anti-ssDNA, RF or CIC in DB mice, in the B6 mice it exerted effects which were comparable to those of PI but considerably weaker, more transient and somewhat delayed. These results are discussed in terms of the importance and significance of strain-dependence for the induction of autoimmune phenomena by PCA and microbial infections.
从羊种布鲁氏菌中提取的具有B细胞促有丝分裂和多克隆激活剂（PCA）活性的接种部分“PI”，经腹腔注射到B6和DB小鼠体内。在B6小鼠中，这导致抗单链DNA抗体水平显著但短暂升高、类风湿因子（RF）的诱导以及循环免疫复合物（CIC）的出现。另一方面，在DB小鼠中，唯一显著的影响是从第7天起血清中CIC出现轻微且短暂的峰值。同样，静脉接种活猪布鲁氏菌对DB小鼠的抗单链DNA、RF或CIC水平没有影响，而在B6小鼠中，其产生的效应与PI相当，但程度较弱、更短暂且有所延迟。就PCA和微生物感染诱导自身免疫现象的品系依赖性的重要性和意义对这些结果进行了讨论。
