Pini Cristiano, Matassa Giovanni, Gelardi Fabrizia, Antunovic Lidija
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20090, Pieve Emanuele, Milan, Italy.
IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089, Rozzano, Milan, Italy.
Eur J Hybrid Imaging. 2023 Mar 20;7(1):6. doi: 10.1186/s41824-023-00164-7.
Merkel Cell Carcinoma (MCC) is a rare primary cutaneous cancer with aggressive behaviour and poor prognosis. Although MCC cells express somatostatin receptors (SSTR), SSTR-targeted PET/CT is not routinely performed in clinical practice. In contrast, the use of [F]FDG PET/CT is more widespread and its prognostic role is well established. We present the case of an MCC patient suspected recurrence who underwent restaging with both [F]FDG and [ Ga]Ga-DOTA-TOC PET/CT. [F]FDG PET/CT showed pathological uptake only in mediastinal lymph nodes, but SSTR imaging also revealed multiple liver and skeletal metastases, leading to significant disease upstaging and relevant changes in the therapeutic management.
默克尔细胞癌（MCC）是一种罕见的原发性皮肤癌，具有侵袭性且预后较差。尽管MCC细胞表达生长抑素受体（SSTR），但在临床实践中，针对SSTR的PET/CT检查并非常规进行。相比之下，[F]FDG PET/CT的应用更为广泛，其预后作用也已得到充分证实。我们报告了一例疑似复发的MCC患者，该患者接受了[F]FDG和[Ga]Ga-DOTA-TOC PET/CT的再分期检查。[F]FDG PET/CT仅显示纵隔淋巴结有异常摄取，但SSTR成像还发现了多处肝脏和骨骼转移，导致疾病分期显著上调，并使治疗方案发生了相关改变。
