Departments of Nuclear Medicine and Radiology, Cantonal Hospital Lucerne, Lucerne, Switzerland.
Clin Nucl Med. 2013 Apr;38(4):283-4. doi: 10.1097/RLU.0b013e318281658e.
Merkel cell carcinoma (MCC) is a rare but very aggressive neuroendocrine tumor of the skin in elderly patients with higher mortality compared with melanoma. No evidence-based standardized chemotherapy exists for metastasized patients.We report the case of an 87-year-old patient with the history of resection of a large MCC of the parietal scalp planned for radiotherapy and staged with FDG PET/CT showing disseminated distant metastases. Ga-DOTATATE PET/CT revealed more extensive tumor load compared with FDG, and due to the intensive expression of somatostatin receptors the patient qualified for Y DOTATOC therapy.
默克尔细胞癌（Merkel cell carcinoma，MCC）是一种罕见但非常侵袭性的皮肤神经内分泌肿瘤，发生于老年患者，其死亡率高于黑色素瘤。对于转移性患者，目前尚无基于循证医学的标准化化疗方案。我们报告了一例 87 岁患者的病例，该患者既往有头皮巨大 MCC 切除术病史，计划行放疗，并进行了 FDG PET/CT 分期，结果显示广泛的远处转移。Ga-DOTATATE PET/CT 显示与 FDG 相比肿瘤负荷更广泛，由于生长抑素受体的强烈表达，该患者有资格接受 Y DOTATOC 治疗。
