新冠病毒疾病中的自然杀伤细胞：从感染到疫苗接种及治疗

Natural killer cells in COVID-19: from infection, to vaccination and therapy.

作者信息

Zafarani Alireza, Razizadeh Mohammad Hossein, Pashangzadeh Salar, Amirzargar Mohammad Reza, Taghavi-Farahabadi Mahsa, Mahmoudi Mohammad

机构信息

Department of Hematology & Blood Banking, School of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran.

Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.

出版信息

Future Virol. 2023 Feb. doi: 10.2217/fvl-2022-0040. Epub 2023 Mar 14.

DOI:10.2217/fvl-2022-0040

PMID:36936055

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10013930/

Abstract

Natural killer (NK) cells are among the most important innate immunity members, which are the first cells that fight against infected cells. The function of these cells is impaired in patients with COVID-19 and they are not able to prevent the spread of the disease or destroy the infected cells. Few studies have evaluated the effects of COVID-19 vaccines on NK cells, though it has been demonstrated that DNA vaccines and BNT162b2 can affect NK cell response. In the present paper, the effects of SARS-CoV-2 on the NK cells during infection, the effect of vaccination on NK cells, and the NK cell-based therapies were reviewed.

摘要

自然杀伤（NK）细胞是最重要的先天性免疫成员之一，是最早对抗受感染细胞的细胞。在新冠肺炎患者中，这些细胞的功能受损，无法阻止疾病传播或破坏受感染细胞。尽管已有研究表明DNA疫苗和BNT162b2可影响NK细胞反应，但很少有研究评估新冠疫苗对NK细胞的影响。本文综述了严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染期间对NK细胞的影响、疫苗接种对NK细胞的影响以及基于NK细胞的治疗方法。