Wawrzyniak Natalia, Gramza-Michałowska Anna, Kurzawa Paweł, Kołodziejski Paweł, Suliburska Joanna
Department of Human Nutrition and Dietetics, Faculty of Food Science and Nutrition, Poznań University of Life Sciences, 31 Wojska Polskiego St., 60-624 Poznan, Poland.
Department of Gastronomy Science and Functional Foods, Faculty of Food Science and Nutrition, Poznań University of Life Sciences, Wojska Polskiego 31, 60-624 Poznan, Poland.
J Food Sci Technol. 2023 Apr;60(4):1402-1413. doi: 10.1007/s13197-023-05686-3. Epub 2023 Feb 10.
Calcium carbonate (CaCO)-enriched pumpkin may serve as a good source of calcium for patients diagnosed with osteoporosis. In this study, we aimed to determine the effect of CaCO-enriched pumpkin on Ca status in ovariectomized rats. The study included 40 female Wistar rats divided into five groups (n = 8). One group was fed with a standard diet (control group), while the other four groups were ovariectomized and received a standard diet (control ovariectomized group), or a diet containing CaCO-enriched pumpkin, alendronate, or both. The nutritional intervention lasted 12 weeks, and then the rats were euthanized. Tissue and blood samples were collected and assessed for the levels of total Ca, estradiol, parathyroid hormone, and procollagen type I N propeptide. In addition, a histological analysis was performed on femurs. The results of the study suggest that CaCO-enriched pumpkin can increase Ca content in femurs and improve bone recovery in ovariectomized rats. Furthermore, enriched pumpkin contributes to Ca accumulation in the kidneys, and this effect is more pronounced in combination with alendronate.
富含碳酸钙（CaCO）的南瓜可能是骨质疏松症患者良好的钙源。在本研究中，我们旨在确定富含CaCO的南瓜对去卵巢大鼠钙状态的影响。该研究包括40只雌性Wistar大鼠，分为五组（n = 8）。一组喂食标准饮食（对照组），而其他四组去卵巢并接受标准饮食（去卵巢对照组），或含有富含CaCO的南瓜、阿仑膦酸钠或两者的饮食。营养干预持续12周，然后对大鼠实施安乐死。收集组织和血液样本并评估总钙、雌二醇、甲状旁腺激素和I型前胶原N端前肽的水平。此外，对股骨进行了组织学分析。研究结果表明，富含CaCO的南瓜可以增加去卵巢大鼠股骨中的钙含量并改善骨恢复。此外，富含南瓜有助于钙在肾脏中的积累，并且这种作用在与阿仑膦酸钠联合使用时更为明显。
