美国感染HIV或有感染HIV风险的女性中的乙型肝炎病毒和丁型肝炎病毒感染
Hepatitis B virus and hepatitis D virus infection in women with or at risk for HIV infection in the United States.
作者信息
Argirion Ilona, Mahale Parag, Pfeiffer Ruth M, Liu Ping, Adimora Adaora A, Akiyama Matthew J, Bolivar Hector H, French Audrey, Plankey Michael, Price Jennifer C, Rana Aadia, Sheth Anandi, Koshiol Jill, Seaberg Eric C, Kuniholm Mark H, Glenn Jeffrey, O'Brien Thomas R
机构信息
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States.
Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States.
出版信息
Front Med (Lausanne). 2023 Mar 2;10:1070420. doi: 10.3389/fmed.2023.1070420. eCollection 2023.
Hepatitis D virus (HDV) requires co-infection with hepatitis B virus (HBV). Human immunodeficiency virus (HIV) shares transmission routes with these viruses. Among 4,932 US women infected with or at-risk for HIV during 1994-2015, HBV surface antigen (HBsAg) positivity was more common in women with HIV (2.8% vs. 1.2%; = 0.001); HDV was more common among participants enrolled during 2013-2015 ( = 0.0004) and those with resolved rather than active hepatitis C (1.9% vs. 0.5%; = 0.02). Among HBsAg-positive women ( = 117), HDV antibody prevalence was 22% and did not vary by HIV status; HDV infection was associated with the presence of advanced fibrosis/cirrhosis at enrollment (adjusted odds ratio, 5.70; 95% confidence interval, 1.46-22.29). Our results demonstrate the importance of HDV testing in HBV-infected US women.
丁型肝炎病毒（HDV）需要与乙型肝炎病毒（HBV）共同感染。人类免疫缺陷病毒（HIV）与这些病毒具有相同的传播途径。在1994年至2015年期间感染HIV或有感染风险的4932名美国女性中，HIV感染女性的乙肝表面抗原（HBsAg）阳性更为常见（2.8%对1.2%；P = 0.001）；HDV在2013年至2015年期间入组的参与者中更为常见（P = 0.0004），并且在丙型肝炎已治愈而非仍处于活动期的参与者中更为常见（1.9%对0.5%；P = 0.02）。在HBsAg阳性女性（n = 117）中，HDV抗体患病率为22%，且不随HIV感染状况而变化；HDV感染与入组时存在晚期纤维化/肝硬化相关（校正比值比，5.70；95%置信区间，1.46 - 22.29）。我们的结果表明在美国HBV感染女性中进行HDV检测的重要性。
Zotero 插件