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表现为累及远端指尖和甲下组织的增大结节的肢端纤维软骨黏液样肿瘤:一例报告

Acral Fibrochondromyxoid Tumor Presenting as Enlarging Nodule Involving the Distal Fingertip and Hyponychium: A Case Report.

作者信息

Miller Rhiannon C, Magro Cynthia M, Melnick Laura E, Lipner Shari R

机构信息

Department of Dermatology, Weill Cornell Medicine, New York, NY, USA.

Department of Pathology, Weill Cornell Medicine, New York, NY, USA.

出版信息

Case Rep Dermatol. 2023 Mar 16;15(1):56-61. doi: 10.1159/000529568. eCollection 2023 Jan-Dec.

DOI:10.1159/000529568
PMID:36936733
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10020937/
Abstract

An acral fibrochondromyxoid tumor is a newly described type of benign soft tissue neoplasm that presents as a single nodular lesion on a finger or toe. There has only been one previous report on this tumor, a case series that described the initial pathologic and clinical findings; however, details on clinical history, physical examination, and outcome are unknown. In this report, we describe a case of a 39-year-old male who presented with a painful enlarging mass involving the distal right 3rd finger and hyponychium. Punch biopsy was performed and the lesion was identified as an acral fibrochondromyxoid tumor on microscopic examination. X-ray showed no bony involvement. The tumor was successfully excised with complete resolution of pain symptoms. We discuss the clinical features and immunohistochemistry findings of our case in the context of the current limited knowledge about this very rare tumor.

摘要

肢端纤维软骨黏液样肿瘤是一种新描述的良性软组织肿瘤,表现为手指或脚趾上的单个结节性病变。此前仅有一篇关于该肿瘤的报道,是一个病例系列,描述了最初的病理和临床发现;然而,临床病史、体格检查及预后的细节尚不清楚。在本报告中,我们描述了一例39岁男性,其右手中指远端及甲下出现一个疼痛性增大的肿块。进行了穿刺活检,显微镜检查显示该病变为肢端纤维软骨黏液样肿瘤。X线检查未发现骨质受累。肿瘤成功切除,疼痛症状完全缓解。我们结合目前对这种非常罕见肿瘤的有限认识,讨论了我们病例的临床特征和免疫组化结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7744/10020937/fec3aa4ecd79/cde-2023-0015-0001-529568_F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7744/10020937/1016772ba4c1/cde-2023-0015-0001-529568_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7744/10020937/39e82901df80/cde-2023-0015-0001-529568_F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7744/10020937/fec3aa4ecd79/cde-2023-0015-0001-529568_F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7744/10020937/1016772ba4c1/cde-2023-0015-0001-529568_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7744/10020937/39e82901df80/cde-2023-0015-0001-529568_F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7744/10020937/fec3aa4ecd79/cde-2023-0015-0001-529568_F3.jpg

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本文引用的文献

1
Acral FibroChondroMyxoid tumor: imaging features of a new entity.肢端纤维软骨黏液样肿瘤:一种新实体的影像学特征。
Skeletal Radiol. 2021 Mar;50(3):603-607. doi: 10.1007/s00256-020-03592-9. Epub 2020 Aug 25.
2
Recurrent novel THBS1-ADGRF5 gene fusion in a new tumor subtype "Acral FibroChondroMyxoid Tumors".在一种新的肿瘤亚型“肢端纤维软骨黏液瘤”中发现了反复出现的新型 THBS1-ADGRF5 基因融合。
Mod Pathol. 2020 Jul;33(7):1360-1368. doi: 10.1038/s41379-020-0493-4. Epub 2020 Feb 11.
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Superficial Acral Fibromyxoma: Literature Review.浅表性肢端纤维黏液瘤:文献综述
Rev Bras Ortop (Sao Paulo). 2019 Sep;54(5):491-496. doi: 10.1016/j.rbo.2017.10.011. Epub 2019 Oct 29.
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ALK rearrangement and overexpression in epithelioid fibrous histiocytoma.上皮样纤维组织细胞瘤中 ALK 重排和过表达。
Mod Pathol. 2015 Jul;28(7):904-12. doi: 10.1038/modpathol.2015.49. Epub 2015 Apr 10.
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Myoepithelial neoplasms of soft tissue: an updated review of the clinicopathologic, immunophenotypic, and genetic features.软组织肌上皮肿瘤:临床病理、免疫表型及遗传学特征的最新综述
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INI1 and GLUT-1 expression in epithelioid sarcoma and its cutaneous neoplastic and nonneoplastic mimics.INI1和GLUT-1在上皮样肉瘤及其皮肤肿瘤性和非肿瘤性模仿病变中的表达
Am J Dermatopathol. 2009 Apr;31(2):152-6. doi: 10.1097/DAD.0b013e31818a5c4f.