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非离心甘蔗糖中多酚对唾液分泌的影响：实验与随机对照试验

Effects of polyphenols in non-centrifugal cane sugar on saliva secretion: and experiments and a randomized controlled trial.

作者信息

Supriya Shakya, Ushikoshi-Nakayama Ryoko, Yamazaki Tomoe, Omagari Daisuke, Aota Keiko, Inoue Hiroko, Matsumoto Naoyuki, Saito Ichiro

机构信息

Department of Pathology, Tsurumi University School of Dental Medicine, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama, Kanagawa 230-8501, Japan.

Department of Oral Medicine, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima 770-8504, Japan.

出版信息

J Clin Biochem Nutr. 2023 Mar;72(2):171-182. doi: 10.3164/jcbn.22-114. Epub 2022 Dec 28.

DOI:10.3164/jcbn.22-114
PMID:36936876
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10017321/
Abstract

This study examined the bioactivities and mechanisms of the non-centrifugal cane sugar polyphenols saponarin, schaftoside, and isoschaftoside in the salivary gland and their effects on salivation. In acute isolated C57BL/6N mouse submandibular gland cells, these polyphenols led to a higher increase in intracellular calcium after stimulation with the muscarinic agonist carbachol. Stimulation of these cells with polyphenols enhanced ATP production, aquaporin-5 translocation to the plasma membrane and eliminated intracellular reactive oxygen species generated by HO. In addition, phosphorylation of endothelial nitric oxide synthase and increased nitric oxide production in vascular endothelial cells were observed. administration of these polyphenols to C57BL/6N male mice resulted in significantly increased blood flow (saponarin,  = 0.040; isoschaftoside,  = 0.010) and salivation (saponarin,  = 0.031). A randomized controlled trial showed that intake of non-centrifugal cane sugar significantly increased saliva secretion compared with placebo ( = 0.003). These data suggest that non-centrifugal cane sugar polyphenols affect several pathways that support salivation and increase saliva secretion by enhancing vasodilation. Hence, non-centrifugal cane sugar polyphenols can be expected to maintain saliva secretion and improve reduced saliva flow.

摘要

本研究考察了非离心甘蔗糖多酚类化合物皂草苷、schaftoside和异schaftoside在唾液腺中的生物活性及作用机制，以及它们对唾液分泌的影响。在急性分离的C57BL/6N小鼠下颌下腺细胞中，这些多酚类化合物在用毒蕈碱激动剂卡巴胆碱刺激后，导致细胞内钙水平有更高的升高。用多酚类化合物刺激这些细胞可增强ATP生成、水通道蛋白-5向质膜的转位，并清除由HO产生的细胞内活性氧。此外，还观察到血管内皮细胞中内皮型一氧化氮合酶的磷酸化及一氧化氮生成增加。给C57BL/6N雄性小鼠施用这些多酚类化合物导致血流量显著增加（皂草苷，P = 0.040；异schaftoside，P = 0.010）和唾液分泌增加（皂草苷，P = 0.031）。一项随机对照试验表明，与安慰剂相比，摄入非离心甘蔗糖显著增加唾液分泌（P = 0.003）。这些数据表明，非离心甘蔗糖多酚影响支持唾液分泌的多种途径，并通过增强血管舒张来增加唾液分泌。因此，非离心甘蔗糖多酚有望维持唾液分泌并改善唾液流量减少的情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/424c/10017321/21862895d6b8/jcbn22-114f09.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/424c/10017321/4c976095453c/jcbn22-114f08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/424c/10017321/21862895d6b8/jcbn22-114f09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/424c/10017321/1b4100c78369/jcbn22-114f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/424c/10017321/260fe4a61d3c/jcbn22-114f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/424c/10017321/2fed4ae6db91/jcbn22-114f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/424c/10017321/7ed849e290ec/jcbn22-114f04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/424c/10017321/952c1dac2a64/jcbn22-114f05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/424c/10017321/a52efd915c86/jcbn22-114f06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/424c/10017321/c1226fe92af8/jcbn22-114f07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/424c/10017321/4c976095453c/jcbn22-114f08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/424c/10017321/21862895d6b8/jcbn22-114f09.jpg

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