Geriatric Unit, Department of Medicine, University of Palermo, 90100 Palermo, Italy.
Faculty of Medicine and Surgery, University of Enna "Kore", 94100 Enna, Italy.
Nutrients. 2022 Feb 20;14(4):889. doi: 10.3390/nu14040889.
A number of factors contribute to the complex process of aging, which finally define whether someone will or not develop age-associated chronic diseases in late life. These determinants comprise genetic susceptibility as well as various behavioral, environmental, and dietary factors, all of which have been shown to influence specific pathways regulating the aging process and the extension of life, which makes longevity a multidimensional phenomenon. Although a "miraculous elixir" or a "nutrition pill" are not plausible, researchers agree on the notion that nutritional factors have major impact on the risk of age-associated chronic non-communicable diseases and mortality. In recent years nutrition research in relation to health outcomes has considerably changed from focusing exclusively on single nutrients to considering combinations of foods rather than nutrients in isolation. Although research on specific nutrients is scientifically valid providing crucial evidence on the mechanisms by which nutrition impacts health, the recent switch targeting the multifaceted synergistic interplay among nutrients, other dietary constituents, and whole foods, has promoted emerging interest on the actions of total dietary patterns. This narrative review aims to describe some specific dietary patterns with evidence of associations with reduction in the incidence of chronic diseases allowing older adults to live a long-lasting and healthier life, and confirming the powerful impact nutrition can exert on healthy aging.
许多因素促成了衰老这一复杂过程,最终决定了一个人是否会在晚年患上与年龄相关的慢性疾病。这些决定因素包括遗传易感性以及各种行为、环境和饮食因素,所有这些因素都已被证明会影响调节衰老过程和寿命延长的特定途径,这使得长寿成为一个多维现象。虽然没有“神奇的长生不老药”或“营养丸”,但研究人员一致认为,营养因素对与年龄相关的慢性非传染性疾病和死亡率的风险有重大影响。近年来,与健康结果相关的营养研究已从单纯关注单一营养素转变为考虑食物组合,而不是孤立的营养素。虽然针对特定营养素的研究在科学上是合理的,为营养影响健康的机制提供了关键证据,但最近针对营养素、其他膳食成分和全食物之间多方面协同相互作用的研究,促进了人们对膳食模式整体作用的新兴趣。本综述旨在描述一些具有降低慢性疾病发病率相关证据的特定饮食模式,使老年人能够长寿和更健康的生活,并证实营养对健康衰老的强大影响。