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揭开致命真菌的面纱:一例表现异常的糖尿病患者鼻眶脑毛霉菌病病例报告

Unmasking the Deadly Fungus: A Case Report of Rhino-Orbital-Cerebral Mucormycosis in a Diabetic Patient With Unusual Presentation.

作者信息

Aljoaid Anas M, Khayat Mohammed, Alkhotani Nashwa

机构信息

Internal Medicine, Al-Noor Specialist Hospital, Makkah, SAU.

Infectious Disease, Al-Noor Specialist Hospital, Makkah, SAU.

出版信息

Cureus. 2023 Mar 15;15(3):e36191. doi: 10.7759/cureus.36191. eCollection 2023 Mar.

DOI:10.7759/cureus.36191
PMID:36937122
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10022839/
Abstract

Mucormycosis (zygomycosis) is a rare, rapidly progressive fungal infection that is opportunistic and usually affects immunocompromised individuals, most commonly patients with diabetes mellitus. It is a fatal infection that requires high clinical suspicion and early disease identification. The global burden of mucormycosis is unknown as it is a rare disease. However, the burden of mucormycosis is increasing worldwide, with the emergence of new risk factors and causative agents. In the Saudi population, the discovered cases and the overall prevalence were low. Herein, we present a case of mucormycosis infection aiming to illustrate the clinical characteristics and the management strategy, besides adding another case to the literature.

摘要

毛霉菌病(接合菌病)是一种罕见的、进展迅速的真菌感染,属于机会性感染,通常影响免疫功能低下的个体,最常见的是糖尿病患者。这是一种致命感染,需要高度的临床怀疑和早期疾病识别。由于毛霉菌病是一种罕见疾病,其全球负担尚不清楚。然而,随着新的危险因素和病原体的出现,毛霉菌病在全球的负担正在增加。在沙特人群中,发现的病例数和总体患病率较低。在此,我们报告一例毛霉菌病感染病例,旨在阐述其临床特征和治疗策略,同时也为文献增添另一病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1148/10022839/39601a88222d/cureus-0015-00000036191-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1148/10022839/53ab1df37c36/cureus-0015-00000036191-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1148/10022839/20825d688210/cureus-0015-00000036191-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1148/10022839/b960f4494a1a/cureus-0015-00000036191-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1148/10022839/39601a88222d/cureus-0015-00000036191-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1148/10022839/53ab1df37c36/cureus-0015-00000036191-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1148/10022839/20825d688210/cureus-0015-00000036191-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1148/10022839/b960f4494a1a/cureus-0015-00000036191-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1148/10022839/39601a88222d/cureus-0015-00000036191-i04.jpg

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本文引用的文献

1
Clinical characteristics and outcome of mucormycosis: A multi-center retrospective analysis in Saudi Arabia over 11 years.毛霉菌病的临床特征与结局:沙特阿拉伯11年多中心回顾性分析
IJID Reg. 2022 Jul 8;4:152-156. doi: 10.1016/j.ijregi.2022.07.004. eCollection 2022 Sep.
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Epidemiology and outcome of zygomycosis: a review of 929 reported cases.毛霉菌病的流行病学与转归:929例报告病例的综述
Clin Infect Dis. 2005 Sep 1;41(5):634-53. doi: 10.1086/432579. Epub 2005 Jul 29.
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