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一名糖尿病患者的毛霉菌病:病例报告及对其病理生理学的深入见解

Mucormycosis in a Diabetic Patient: A Case Report with an Insight into Its Pathophysiology.

作者信息

Afroze Syeda Neelam, Korlepara Rajani, Rao Guttikonda Venkateswara, Madala Jayakiran

机构信息

Department of Oral Pathology and Microbiology, Mamata Dental College, Khammam, Telangana, India.

出版信息

Contemp Clin Dent. 2017 Oct-Dec;8(4):662-666. doi: 10.4103/ccd.ccd_558_17.

Abstract

Mucormycosis is one of the most rapidly progressing and fulminant forms of fungal infection which usually begins in the nose and paranasal sinuses following inhalation of fungal spores. It is caused by organisms of the subphylum Mucormycotina, including genera as Absidia, Mucor, Rhizomucor, and Rhizopus. The incidence of mucormycosis is approximately 1.7 cases per 1,000,000 inhabitants per year. Mucormycosis affecting the maxilla is rare because of rich blood vessel supply of maxillofacial areas although more virulent fungi such as Mucor can overcome this difficulty. The common form of this infection is seen in the rhinomaxillary region and in patients with immunocompromised state such as diabetes. Hence, early diagnosis of this potentially life-threatening disease and prompt treatment is of prime importance in reducing the mortality rate.

摘要

毛霉病是最迅速进展和暴发性的真菌感染形式之一,通常在吸入真菌孢子后始于鼻腔和鼻窦。它由毛霉亚门的生物体引起,包括犁头霉属、毛霉属、根毛霉属和根霉属等属。毛霉病的发病率约为每年每100万居民中有1.7例。尽管像毛霉这样毒性更强的真菌可以克服这一困难,但由于颌面部区域丰富的血管供应,影响上颌骨的毛霉病很少见。这种感染的常见形式见于鼻上颌区域以及免疫功能低下的患者,如糖尿病患者。因此,对这种潜在的危及生命的疾病进行早期诊断和及时治疗对于降低死亡率至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f09/5754995/92e873184f3b/CCD-8-662-g001.jpg

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