Huang Yuanzheng, Wang Zhihui, Gong Junni, Zhu Dandan, Chen Wang, Li Fangzhou, Liang Xing-Jie, Liu Xiaoxuan
State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing 210009, Jiangsu, China.
Chinese Academy of Sciences (CAS) Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, China.
Explor Target Antitumor Ther. 2023;4(1):89-101. doi: 10.37349/etat.2023.00124. Epub 2023 Feb 28.
Macrophages, as ubiquitous and functionally diverse immune cells, play a central role in innate immunity and initiate adaptive immunity. Especially, tumor-associated macrophages (TAMs) are crucial contributors to the tumorigenesis and development of cancer. Thus, macrophages are emerging potential targets for cancer treatment. Among the numerous targeted therapeutic options, gene therapy is one of the most potential therapeutic strategies via directly and specifically regulating biological functions of macrophages at the gene level for cancer treatment. This short review briefly introduces the characteristics of macrophage populations, the functions of TAM in the occurrence, and the progress of cancer. It also summarized some representative examples to highlight the current progress in TAM-targeted gene therapy. The review hopes to provide new insights into macrophage-targeted gene therapy for precision cancer therapy.
巨噬细胞作为普遍存在且功能多样的免疫细胞，在固有免疫中发挥核心作用并启动适应性免疫。特别是，肿瘤相关巨噬细胞（TAM）是癌症发生和发展的关键促成因素。因此，巨噬细胞正成为癌症治疗的潜在靶点。在众多靶向治疗选择中，基因治疗是最具潜力的治疗策略之一，可通过在基因水平直接且特异性地调节巨噬细胞的生物学功能来治疗癌症。这篇简短的综述简要介绍了巨噬细胞群体的特征、TAM在癌症发生中的作用以及进展。它还总结了一些代表性例子以突出TAM靶向基因治疗的当前进展。该综述希望为精准癌症治疗的巨噬细胞靶向基因治疗提供新的见解。
