非小细胞肺癌中超声造影与微血管密度的相关性：一项前瞻性研究。
Correlations between contrast-enhanced ultrasound and microvessel density in non-small cell lung cancer: A prospective study.
作者信息
Chen Wuxi, Zhang Yuxin, Tang Jiaxin, Wei Dongjun, Liao Haixing, Zhang Shiyu, He Liantu, Tang Qing
机构信息
Department of Ultrasound, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, the First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
出版信息
Front Oncol. 2023 Mar 2;13:1086251. doi: 10.3389/fonc.2023.1086251. eCollection 2023.
BACKGROUND
Immunohistochemical microvessel density (MVD) is an early indicator of angiogenesis and it could be used to evaluate the therapeutic efficacy of non-small cell lung cancer (NSCLC). We sought to identify the ability of contrast-enhanced ultrasound (CEUS) in evaluating MVD of subpleural NSCLC.
METHODS
We prospectively collected CEUS data of NSCLC confirmed by ultrasound-guided transthoracic needle biopsy from October 2019 to February 2021, The MVD of NSCLC counted by CD34-positive vessels of immunohistochemical staining. Microflow enhancement (MFE) of CEUS was divided into "dead wood", "cotton", and "vascular" patterns. Pathology subgroup and MVD between different MFE patterns were analyzed, respectively. The arrival time, time to peak, peak intensity (PI), and area under curve (AUC) derivefrom time-intensity curve of CEUS with MVD in NSCLC and its pathological subgroups (adenocarcinoma and squamous cell carcinoma) were subjected to correlation analysis.
RESULTS
A total of 87 patients were included in this study, consisting of 53 cases of adenocarcinoma and 34 cases of squamous cell carcinoma with a mean MVD of 27.8 ± 12.2 mm. There was a significant statistical difference in MFE patterns between two pathological subgroups ( < 0.05). Besides, the MVD of "cotton" and "vascular" patterns were significantly higher than that of "dead wood" pattern (both of < 0.05), whereas there was no significant difference in MVD between "cotton" pattern and "vascular" pattern. PI and AUC of CEUS were positively correlated with the MVD of NSCLC (r = 0.497, < 0.001, and r = 0.367, < 0.001, respectively). Besides, PI and AUC of CEUS were positively correlated with the MVD of squamous cell carcinoma (r = 0.802, and r = 0.663, respectively; both of < 0.001). Only the PI was positively correlated with the MVD of lung adenocarcinoma (r = 0.288, = 0.037).
CONCLUSIONS
MFE patterns and quantitative parameters of CEUS had good correlation with MVD of NSCLC, especially in squamous cell carcinoma.
背景
免疫组织化学微血管密度（MVD）是血管生成的早期指标，可用于评估非小细胞肺癌（NSCLC）的治疗效果。我们旨在确定超声造影（CEUS）评估胸膜下NSCLC的MVD的能力。
方法
前瞻性收集2019年10月至2021年2月经超声引导经胸针吸活检确诊的NSCLC的CEUS数据，通过免疫组织化学染色CD34阳性血管计数NSCLC的MVD。CEUS的微血流增强（MFE）分为“枯木”、“棉花”和“血管”型。分别分析不同MFE类型之间的病理亚组和MVD。对NSCLC及其病理亚组（腺癌和鳞状细胞癌）中CEUS时间-强度曲线得出的达峰时间、峰值时间、峰值强度（PI）和曲线下面积（AUC）与MVD进行相关性分析。
结果
本研究共纳入87例患者，其中腺癌53例，鳞状细胞癌34例，平均MVD为27.8±12.2/mm。两个病理亚组之间的MFE类型存在显著统计学差异（<0.05）。此外，“棉花”型和“血管”型的MVD显著高于“枯木”型（均<0.05），而“棉花”型和“血管”型之间的MVD无显著差异。CEUS的PI和AUC与NSCLC的MVD呈正相关（r=0.497，<0.001；r=0.367，<0.001）。此外，CEUS的PI和AUC与鳞状细胞癌的MVD呈正相关（分别为r=0.802和r=0.663；均<0.001）。仅PI与肺腺癌的MVD呈正相关（r=0.288，=0.037）。
结论
CEUS的MFE类型和定量参数与NSCLC的MVD具有良好的相关性，尤其是在鳞状细胞癌中。
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