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外周血中性粒细胞-淋巴细胞比值与前列腺癌 CD34 表达的相关性。

Correlation between peripheral blood neutrophil-lymphocyte ratio and CD34 expression in prostate cancer.

机构信息

Department of Urology, Yancheng Third People's Hospital, Yancheng, 224000, Jiangsu, China.

Department of Urology, Xuzhou Medical College, Xuzhou, 221000, Jiangsu, China.

出版信息

BMC Cancer. 2020 Sep 22;20(1):900. doi: 10.1186/s12885-020-07382-3.

DOI:10.1186/s12885-020-07382-3
PMID:32962642
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7510314/
Abstract

BACKGROUNDS

The association of neutrophil-lymphocyte ratio (NLR) and CD34 expression level with PSA level, Gleason score, and clinical stage was investigated in patients with prostate cancer. The correlation between NLR and CD34 expression was also investigated to provide evidence supporting the use of NLR for predicting the prognosis of prostate cancer patients.

METHODS

Clinical data of 75 patients diagnosed with prostate cancer by prostate aspiration biopsy were retrospectively analyzed. The correlation between NLR, CD34 expression, and clinicopathological characteristics was analyzed using the χ2 test and one-way analysis of variance. The correlation between NLR and CD34 was determined using the Pearson coefficient. Disease free survival was estimated by Kaplan-Meier analysis.

RESULTS

Both NLR and CD34 expression were significantly positively correlated with PSA, Gleason score, and clinical stage (P < 0.05 both). Patients in the NLR/CD34 group were characterized by high PSA level and Gleason score and late clinical stage. NLR was positively correlated with CD34 expression (r = 0.529, P < 0.001).

CONCLUSIONS

Pretreatment NLR was a valuable marker of prognosis in prostate cancer. NLR is positively correlated with CD34 expression.

摘要

背景

本研究旨在探讨中性粒细胞与淋巴细胞比值（NLR）和 CD34 表达水平与前列腺癌患者的 PSA 水平、Gleason 评分和临床分期的相关性。同时，还分析了 NLR 与 CD34 表达之间的相关性，为 NLR 预测前列腺癌患者预后提供依据。

方法

回顾性分析经前列腺穿刺活检诊断为前列腺癌的 75 例患者的临床资料。采用卡方检验和单因素方差分析分析 NLR、CD34 表达与临床病理特征的相关性。采用 Pearson 系数确定 NLR 与 CD34 之间的相关性。采用 Kaplan-Meier 分析估计无病生存率。

结果

NLR 和 CD34 表达均与 PSA、Gleason 评分和临床分期呈显著正相关（均 P<0.05）。NLR/CD34 组患者具有较高的 PSA 水平和 Gleason 评分以及晚期临床分期。NLR 与 CD34 表达呈正相关（r=0.529，P<0.001）。

结论

治疗前 NLR 是前列腺癌预后的一个有价值的标志物。NLR 与 CD34 表达呈正相关。

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