大规模成像下迷走神经刺激期间大脑皮层与海马体的神经相互作用
Cerebral cortex and hippocampus neural interaction during vagus nerve stimulation under large-scale imaging.
作者信息
Xu Hanyun, Jin Tingting, Zhang Rujin, Xie Hao, Zhuang Chaowei, Zhang Yanyang, Kong Dongsheng, Xiao Guihua, Yu Xinguang
机构信息
Chinese PLA Medical School, Beijing, China.
Department of Neurosurgery, The First Medical Center of Chinese PLA General Hospital, Beijing, China.
出版信息
Front Neurosci. 2023 Mar 2;17:1131063. doi: 10.3389/fnins.2023.1131063. eCollection 2023.
OBJECTIVE
The purpose of this study was to study mechanisms of VNS modulation from a single neuron perspective utilizing a practical observation platform with single neuron resolution and widefield, real-time imaging coupled with an animal model simultaneously exposing the cerebral cortex and the hippocampus.
METHODS
We utilized the observation platform characterized of widefield of view, real-time imaging, and high spatiotemporal resolution to obtain the neuronal activities in the cerebral cortex and the hippocampus during VNS in awake states and under anesthesia.
RESULTS
Some neurons in the hippocampus were tightly related to VNS modulation, and varied types of neurons showed distinct responses to VNS modulation.
CONCLUSION
We utilized such an observation platform coupled with a novel animal model to obtain more information on neuron activities in the cerebral cortex and the hippocampus, providing an effective method to further study the mechanisms of therapeutic effects modulated by VNS.
目的
本研究的目的是利用一个具有单神经元分辨率和宽视野、实时成像功能的实用观察平台，并结合同时暴露大脑皮层和海马体的动物模型，从单个神经元的角度研究迷走神经刺激（VNS）调节的机制。
方法
我们利用具有宽视野、实时成像和高时空分辨率特点的观察平台，获取清醒状态和麻醉状态下VNS期间大脑皮层和海马体中的神经元活动。
结果
海马体中的一些神经元与VNS调节密切相关，不同类型的神经元对VNS调节表现出不同的反应。
结论
我们利用这样一个观察平台结合一种新型动物模型，获得了关于大脑皮层和海马体中神经元活动的更多信息，为进一步研究VNS调节治疗效果的机制提供了一种有效方法。
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