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大规模成像下迷走神经刺激期间大脑皮层与海马体的神经相互作用

Cerebral cortex and hippocampus neural interaction during vagus nerve stimulation under large-scale imaging.

作者信息

Xu Hanyun, Jin Tingting, Zhang Rujin, Xie Hao, Zhuang Chaowei, Zhang Yanyang, Kong Dongsheng, Xiao Guihua, Yu Xinguang

机构信息

Chinese PLA Medical School, Beijing, China.

Department of Neurosurgery, The First Medical Center of Chinese PLA General Hospital, Beijing, China.

出版信息

Front Neurosci. 2023 Mar 2;17:1131063. doi: 10.3389/fnins.2023.1131063. eCollection 2023.

DOI:10.3389/fnins.2023.1131063
PMID:36937685
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10017477/
Abstract

OBJECTIVE

The purpose of this study was to study mechanisms of VNS modulation from a single neuron perspective utilizing a practical observation platform with single neuron resolution and widefield, real-time imaging coupled with an animal model simultaneously exposing the cerebral cortex and the hippocampus.

METHODS

We utilized the observation platform characterized of widefield of view, real-time imaging, and high spatiotemporal resolution to obtain the neuronal activities in the cerebral cortex and the hippocampus during VNS in awake states and under anesthesia.

RESULTS

Some neurons in the hippocampus were tightly related to VNS modulation, and varied types of neurons showed distinct responses to VNS modulation.

CONCLUSION

We utilized such an observation platform coupled with a novel animal model to obtain more information on neuron activities in the cerebral cortex and the hippocampus, providing an effective method to further study the mechanisms of therapeutic effects modulated by VNS.

摘要

目的

本研究的目的是利用一个具有单神经元分辨率和宽视野、实时成像功能的实用观察平台，并结合同时暴露大脑皮层和海马体的动物模型，从单个神经元的角度研究迷走神经刺激（VNS）调节的机制。

方法

我们利用具有宽视野、实时成像和高时空分辨率特点的观察平台，获取清醒状态和麻醉状态下VNS期间大脑皮层和海马体中的神经元活动。

结果

海马体中的一些神经元与VNS调节密切相关，不同类型的神经元对VNS调节表现出不同的反应。

结论

我们利用这样一个观察平台结合一种新型动物模型，获得了关于大脑皮层和海马体中神经元活动的更多信息，为进一步研究VNS调节治疗效果的机制提供了一种有效方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7f8/10017477/0ca0ef1c3962/fnins-17-1131063-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7f8/10017477/8fbac30a1a4a/fnins-17-1131063-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7f8/10017477/1e5e522aa070/fnins-17-1131063-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7f8/10017477/1e100dd68225/fnins-17-1131063-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7f8/10017477/4fd378c4f8a1/fnins-17-1131063-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7f8/10017477/0ca0ef1c3962/fnins-17-1131063-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7f8/10017477/8fbac30a1a4a/fnins-17-1131063-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7f8/10017477/1e5e522aa070/fnins-17-1131063-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7f8/10017477/1e100dd68225/fnins-17-1131063-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7f8/10017477/4fd378c4f8a1/fnins-17-1131063-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7f8/10017477/0ca0ef1c3962/fnins-17-1131063-g005.jpg

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本文引用的文献

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Technical Note: Modulation of fMRI brainstem responses by transcutaneous vagus nerve stimulation.技术说明：经皮迷走神经刺激调制 fMRI 脑干反应。
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Short-Term Effects of Vagus Nerve Stimulation on Learning and Evoked Activity in Auditory Cortex.迷走神经刺激对听觉皮层学习和诱发电活动的短期影响。
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Vagus nerve stimulation in brain diseases: Therapeutic applications and biological mechanisms.
迷走神经刺激在脑部疾病中的应用：治疗应用和生物学机制。
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Graded recruitment of pupil-linked neuromodulation by parametric stimulation of the vagus nerve.参数刺激迷走神经对瞳孔相关神经调节的分级募集。
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Vagus nerve stimulation induces widespread cortical and behavioral activation.迷走神经刺激可诱导广泛的皮层和行为激活。
Curr Biol. 2021 May 24;31(10):2088-2098.e3. doi: 10.1016/j.cub.2021.02.049. Epub 2021 Mar 18.
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Optogenetic Stimulation of Prelimbic Pyramidal Neurons Maintains Fear Memories and Modulates Amygdala Pyramidal Neuron Transcriptome.前边缘层锥体神经元的光遗传学刺激维持恐惧记忆并调节杏仁核锥体神经元转录组。
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Simultaneous calcium recordings of hippocampal CA1 and primary motor cortex M1 and their relations to behavioral activities in freely moving epileptic mice.在自由活动的癫痫小鼠中同时记录海马 CA1 和初级运动皮层 M1 的钙信号，并分析其与行为活动的关系。
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