Yuan Runzhu, Tan Yao, Sun Ping-Hui, Qin Bo, Liang Zhen
School of Medicine, The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen People's Hospital, Shenzhen, China.
Shenzhen Aier Eye Hospital, Aier Eye Hospital, Jinan University, Shenzhen, China.
Front Pharmacol. 2023 Mar 3;14:1122890. doi: 10.3389/fphar.2023.1122890. eCollection 2023.
Cancer, also known as a malignant tumor, is caused by the activation of oncogenes, which leads to the uncontrolled proliferation of cells that results in swelling. According to the World Health Organization (WHO), cancer is one of the main causes of death worldwide. The main variables limiting the efficacy of anti-tumor treatments are side effects and drug resistance. The search for natural, safe, low toxicity, and efficient chemical compounds in tumor research is essential. Berberine is a pentacyclic isoquinoline quaternary ammonium alkaloid isolated from Berberis and Coptis that has long been used in clinical settings. Studies in recent years have reported the use of berberine in cancer treatment. In this study, we performed a bibliometric analysis of berberine- and tumor-related research. Relevant articles from January 1, 2002, to December 31, 2021, were identified from the Web of Science Core Collection (WOSCC) of Clarivate Analytics. Microsoft Excel, CiteSpace, VOSviewer, and an online platform were used for the literary metrology analysis. A total of 1368 publications had unique characteristics. Publications from China were the most common (783 articles), and Y. B. Feng (from China) was the most productive author, with the highest total citations. China Medical University (Taiwan) and Sun Yat-sen University (China) were the two organizations with the largest numbers of publications (36 each). was the most commonly occurring journal (29 articles). The present body of research is focused on the mechanism, molecular docking, and oxidative stress of berberine in tumors. Research on berberine and tumors was thoroughly reviewed using knowledge map and bibliometric methods. The results of this study reveal the dynamic evolution of berberine and tumor research and provide a basis for strategic planning in cancer research.
癌症，也被称为恶性肿瘤，是由致癌基因的激活引起的，这会导致细胞不受控制地增殖，进而引发肿胀。根据世界卫生组织（WHO）的数据，癌症是全球主要的死亡原因之一。限制抗肿瘤治疗效果的主要变量是副作用和耐药性。在肿瘤研究中寻找天然、安全、低毒且高效的化合物至关重要。黄连素是一种从黄柏和黄连中分离出的五环异喹啉季铵生物碱，长期以来一直用于临床。近年来的研究报道了黄连素在癌症治疗中的应用。在本研究中，我们对黄连素与肿瘤相关的研究进行了文献计量分析。从科睿唯安的Web of Science核心合集（WOSCC）中识别出了2002年1月1日至2021年12月31日期间的相关文章。使用Microsoft Excel、CiteSpace、VOSviewer和一个在线平台进行文献计量分析。共有1368篇出版物具有独特特征。来自中国的出版物最为常见（783篇文章），Y. B. Feng（来自中国）是产出最多的作者，总被引次数最高。中国医科大学（台湾）和中山大学（中国）是出版物数量最多的两个机构（各36篇）。《 》是最常出现的期刊（29篇文章）。目前的研究主体集中在黄连素在肿瘤中的作用机制、分子对接和氧化应激方面。利用知识图谱和文献计量方法对黄连素与肿瘤的研究进行了全面综述。本研究结果揭示了黄连素与肿瘤研究的动态演变，并为癌症研究的战略规划提供了依据。
