Cao Siyang, Pang Yingchen, Wei Yihao, Zeng Hui, Zhang Hua
Department of Orthopaedics, Sports Injury Division, Fujian Medical University Union Hospital, Fuzhou, Fujian, People's Republic of China.
Department of Pulmonary and Critical Care Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangdong, People's Republic of China.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Aug 12. doi: 10.1007/s00210-025-04497-x.
Cuproptosis, an emerging modality of regulated cell death triggered by intracellular copper accumulation, has recently garnered increasing scientific interest due to its therapeutic potential across a spectrum of pathological conditions. The convergence of this novel cell death mechanism with nanomedicine has catalyzed swift progress in designing therapeutic modalities, offering new avenues for precision-targeted interventions. Despite this progress, systematic evaluations of nanocuproptosis remain scarce. To address this gap, we conducted a scientometric analysis of research published between 2014 and 2024. The dataset utilized in this study was extracted from the Web of Science Core Collection and subsequently subjected to in-depth analysis using a suite of scientometric methodologies and visualization frameworks. The analytical outcomes underscore China's predominant influence within this research domain, contributing 78.04% of all publications and shaping the direction of research. Notable institutions include the Chinese Academy of Sciences, Sichuan University, and Huazhong University of Science and Technology. Additionally, Liudmila Puchkova is identified as the most productive researcher, while Advanced Healthcare Materials emerges as the top journal publishing related studies. The analysis also reveals key disease areas associated with nanocuproptosis research, such as hepatocellular carcinoma, glioma, melanoma, pancreatic neoplasms, and triple-negative breast neoplasms. This comprehensive scientometric study provides valuable insights for both established and early-career researchers, facilitating rapid access to critical information and supporting further advances in the field.
铜死亡是一种由细胞内铜积累引发的新型程序性细胞死亡方式,由于其在一系列病理状况下的治疗潜力,最近受到了越来越多的科学关注。这种新型细胞死亡机制与纳米医学的结合,推动了治疗方式设计的迅速进展,为精准靶向干预提供了新途径。尽管取得了这一进展,但对纳米铜死亡的系统评估仍然很少。为了填补这一空白,我们对2014年至2024年发表的研究进行了科学计量分析。本研究中使用的数据集从科学网核心合集提取,随后使用一套科学计量方法和可视化框架进行深入分析。分析结果突显了中国在该研究领域的主导影响力,贡献了所有出版物的78.04%,并塑造了研究方向。知名机构包括中国科学院、四川大学和华中科技大学。此外,柳德米拉·普奇科娃被确定为产出最多的研究人员,而《先进医疗材料》则是发表相关研究的顶级期刊。分析还揭示了与纳米铜死亡研究相关的关键疾病领域,如肝细胞癌、胶质瘤、黑色素瘤、胰腺肿瘤和三阴性乳腺肿瘤。这项全面的科学计量研究为资深研究人员和初入职场的研究人员都提供了有价值的见解,有助于快速获取关键信息,并支持该领域的进一步发展。
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